Leyton Orient are set to be without skipper Nathan Clarke.
The defender suffered a rib injury during the second half of Saturday's 2-0 win at Shrewsbury and was replaced by Elliot Omozusi, who made his second appearance since rejoining the club in January.
Omozusi could now start at right-back with Scott Cuthbert reverting to centre-half in place of Clarke.
Strikers David Mooney (thigh) and Shaun Batt (hamstring) missed out at the weekend and will be checked over, while defender Gary Sawyer and goalkeeper Lee Butcher (both knee) are still on the sidelines.
Midfielders Martin Rowlands and Jimmy Smith could return to the starting line-up if boss Russell Slade opts to make changes for their third game in seven days.
Sam Sodje can return to the Portsmouth squad.
The defender has completed a three-match ban after he was sent off against Oldham last month.
However, Sodje will be among the substitutes at best after Pompey made it back-to-back victories - after a 23-game winless run - by beating fellow strugglers Bury 2-0 on Saturday.
He will be joined on the bench by full-back Shaun Cooper, who has recovered from a hip injury.
Striker John Akinde will also be added to the squad if he shakes off the sickness bug which sidelined him at the weekend.
Academy winger Jack Maloney came on for his league debut towards the end against Bury and should be involved again.