Exeter boss Paul Tisdale will be boosted by the return of experienced midfielder Mark Molesley.
The former Bournemouth attacker has missed the Grecians' last three matches after a red card at Port Vale and he admitted it has been difficult to watch his side from the stands.
"I'm not a very good watcher and around kick off time I'm a bit miserable and moody," he said. "I was really gutted with the red card but the games have come thick and fast so its over before I know it. I had to take the positives out of it and I can't dwell on it.
"I was gutted and frustrated but I just had to focus on keeping my fitness and being ready to go."
Molesley is likely to be involved at St James Park along with winger Jake Gosling, who is pushing for a start after impressing in City's last two home games. John O'Flynn played for 45 minutes in the 0-0 draw at Fleetwood and will also be hoping for the nod from the start.
City, in the final play-off spot, know a win against Martin Allen's men could see them rise as high as third in the table.
Chris Whelpdale will be assessed ahead of the midweek encounter as the League Two leaders look to stretch their five-point lead at the summit of the table.
The midfielder was substituted in the 68th minute of Saturday's 2-1 win over Plymouth carrying a knock, coming shortly after he netted what turned out to be the winner.
Forward Myles Weston is again 50/50 for the trip to Devon as he looks to make his comeback from a foot injury and will also be monitored.
The game is likely to come too soon for midfielders Andy Frampton (concussion) and Charlie Allen (wrist) although they are not far off their respective returns.
Manager Martin Allen is sure to tinker with his side as he looks to manage three matches in the space of a week, with the likes of Charlie Lee, Deon Burton, Danny East and Michael Richardson pushing for starts.