The hosts have no fresh injury worries as they look to bounce back from the 4-1 defeat at Rochdale in midweek.
The Chairboys recorded impressive wins over Torquay and Fleetwood before the disappointing defeat at Spotland which left them 11 points clear of the relegation zone ahead of the clash with the Millers.
"We're still 14th and there's still a lot of teams beneath us," player-manager Gareth Ainsworth told the club's official website.
"I still want another win to make sure. There are things to work on and I'll be a busy man in the lead up to the Rotherham game."
Should Ainsworth decide to ring the changes the likes of Jo Kuffour, Bruno Andrade and Leon Johnson could be given the nod against an in-form Rotherham side just two points off the automatic promotion places.
The visitors will be without the suspended Kari Arnason.
The Iceland international was sent off during Saturday's damaging 2-1 home defeat to Dagenham and must now serve a two-game ban.
Mark Bradley came on after Arnason's departure as manager Steve Evans reshuffled his back line, but he suffered an ankle injury and is unlikely to be fit after having X-rays on Monday morning.
Craig Morgan is the likely replacement at centre-half and if selected will make his first appearance since November following a broken foot.
On-loan winger Daniel Kearns has missed the last four games with a hamstring injury, but is expected to make the squad.
The Millers will be glad to hit the road again after Saturday's reverse at the New York Stadium as they have lost just one of their last 10 league games away from home.