Gary Doherty could start for Wycombe after marking his return to action after five months on the sidelines with a goal against Rotherham.
The experienced Northern Ireland international stepped off the bench to nod home the equaliser in the 2-2 draw with the Millers.
Leon Johnson should be available again after missing Tuesday due to family reasons but Anthony Stewart could be out for the rest of the season after having an operation on a fractured hand.
Captain Dave Winfield went off with a hip problem on Tuesday night and is a doubt as is Matt McClure who suffered an ankle injury.
The Chairboys are 12 points clear of the relegation zone in the league after losing just one of their last four matches.
Northampton make the short trip with an unchanged squad.
Cobblers boss Aidy Boothroyd must decide whether to make changes following his side's 1-1 draw with Morecambe in midweek.
Leading scorer Adebayo Akinfenwa was rested again at the Globe Arena, coming on as a substitute midway through the second half for the second game in succession.
With Alex Nicholls the only absentee as he continues his recovery from a broken leg, 17-goal striker Akinfenwa is one of many options available to Boothroyd.
Fellow forward Clive Platt and midfielder Lewis Hornby are pushing for recalls after being benched against the Shrimps, while midfielder Luke Guttridge and striker Jake Robinson are also options.
Northampton are unbeaten in their last six visits to WYcombe, drawing four times and winning twice.