Scunthorpe skipper Paul Reid is expected to prove his fitness in time for the home derby clash.
Reid sustained an ankle injury in last week's defeat at Notts County and was replaced early in the second half by Niall Canavan.
Canavan will return to the starting line-up alongside David Mirfin in central defence if Reid fails to make it.
Fellow defender Eddie Nolan took a knock to the back at County, but is also expected to start, while Christian Ribeiro could return to the squad following a hamstring injury.
Boss Brian Laws must decide whether to continue with teenager Anthony Forde, who made his debut in midfield last week following his arrival on loan from Wolves while striker Akpo Sodje shook off a foot problem to start and is likely to resume his partnership up front with Karl Hawley.
The Iron, who have lost their last three league games and five of their previous six, are aiming to climb out of the relegation zone with victory.
Doncaster are waiting for news on John Lundstram's injury ahead of the short trip to the Iron.
On-loan midfielder Lundstram suffered an ankle injury during the 1-1 home draw with Portsmouth last weekend, with the problem forcing the Everton teenager to withdraw from the England Under-19 squad for Thursday night's friendly against Turkey.
Lundstram returned to Goodison Park for treatment and Rovers boss Brian Flynn is awaiting the verdict.
"We're hoping for good news on John," said Flynn. "He was disappointed to miss out for England but he was quite positive when I spoke to him last Sunday.
"Everton were quite confident he'd be okay from the contact I've had with them and it was best all-round that he went back to them for treatment."
Without Lundstram, Flynn would be short in midfield as another loanee Dean Furman is away on international duty with South Africa and David Syers (ankle) is still injured.
With promotion rivals Sheffield United and Brentford kicking off at 12.45pm on Saturday, Doncaster could find their lead at the top of the table cut down to one point or have been replaced at the summit by the Bees by the time they start at Glanford Park.