Gillingham will hand late fitness tests to four players but Andy Frampton definitely misses out as he starts a three-match suspension.
Midfielder Frampton saw red in the late stages of Tuesday's 1-1 draw at Rochdale and now misses the next three games as the Gills aim to consolidate their lead at the top of the table.
Chris Whelpdale was forced off midway through the first half at Spotland and now faces a fitness battle, as does his replacement Charlie Lee.
Matters went from bad to worse in midweek as fellow midfielder Bradley Dack was then substituted due to injury after the break.
Forward Myles Weston will also again be assessed having missed the last five matches with an ankle problem, while Gillingham have been unable to extend Michael Richardson's loan spell and he has now returned to Newcastle.
Accrington will be without top scorer Romauld Boco.
Boco is away on international duty with Benin for their World Cup qualifier against Algeria, giving manager Leam Richardson a place to fill in attack.
Padraig Amond is back in training following an abductor problem and is hoping to earn a place on the bench.
Defender Nicky Hunt is definitely ruled out as he continues to struggle with a hamstring injury.
In-form Lee Molyneux will start along with Francis Jeffers, who scored his first goals in English football in over four years in the 4-0 win against AFC Wimbledon.
Stanley are looking to record three consecutive league victories for the first time since December 2011 but face a stern test against Martin Allen's table toppers.