Northampton will have an unchanged squad.
The Cobblers have not played since March 12 after last Saturday's trip to Wycombe was postponed due to a waterlogged pitch.
Ahead of that game, Aidy Boothroyd was mulling over whether to make changes following the 1-1 draw against Morecambe - and the Town boss faces the same decision this weekend.
Leading scorer Adebayo Akinfenwa was rested again at the Globe Arena, coming on as a substitute midway through the second half for the second game in succession.
With Alex Nicholls the only absentee as he continues his recovery from a broken leg, 17-goal striker Akinfenwa is one of many options available to Boothroyd.
Fellow forward Clive Platt and midfielder Lewis Hornby are pushing for recalls after being benched against the Shrimps, while midfielder Luke Guttridge and striker Jake Robinson are also options.
Northampton slipped to sixth in the table last weekend after they were left kicking their heels.
Promotion rivals Port Vale, Cheltenham and Exeter all took full advantage of the Cobblers' inactivity with victories, with the Robins and Grecians leapfrogging Boothroyd's side in the standings.
Oxford boss Chris Wilder has no fresh injury concerns as his side prepare for the crucial clash.
The U's travel to Sixfields knowing defeat could leave them nine points adrift of the top seven with six games remaining.
And Wilder could include Jon-Paul Pittman on the bench after the forward returned to training following his dislocated shoulder.
The former Crawley and Wycombe forward has been missing since December and he looks set to feature in the matchday squad.
Oxford have lost just two in their last eight games but their play-off hopes suffered a blow when Chesterfield won 1-0 at the Kassam last weekend.
The U's remain without long-term injury victims goalkeeper Ryan Clarke (shoulder), striker Justin Richards (knee) and midfielder Peter Leven (knee).