Rotherham manager Steve Evans will make changes to his side.
The Millers saw their automatic promotion hopes suffer a damaging blow when losing 3-0 at Cheltenham last weekend and realistically only three points will do on Saturday.
Evans will recall Kari Arnason after he served a two-game ban, with the Iceland international set to come back in midfield, possibly at the expense of Michael O'Connor or David Noble.
There could also be a change in goal with Scott Shearer back fit again after several months out with knee and elbow injuries, with Andy Warrington's place under threat.
Daniel Kearns is another option for the Millers and the loanee could start on the left instead of Ben Pringle.
The Millers have only won one of their last six games and their assault on a top-three spot will realistically be over if they lose to the Grecians, who arrive in South Yorkshire two points better off than their hosts.
Exeter's new signing Anton Rodgers is set to be involved.
The 20-year-old Brighton midfielder, who has joined on loan until the end of the season, has boosted Paul Tisdale's midfield options for the run-in after injuries to a number of key players in that department.
Matt Oakley (shoulder), Tommy Doherty (back), Alan Gow and Liam Sercombe (both ankle), are all sidelined but the arrival of Rodgers and fellow loanee Lawson D'Ath from Reading have filled the void.
John O'Flynn will hope to keep his place after netting in the 4-1 win over Bradford with top scorer Jamie Cureton pushing for a recall after being an unused substitute against the Bantams.
Fifth-placed Exeter make their first trip to the New York Stadium two points ahead of the Millers as they look to make an immediate return to League One.