Plymouth defender Curtis Nelson is set to return for the Devon derby.
The youngster had been sidelined by a persistent groin problem since late January but has returned to training and is set to be involved.
The Argyle youth product's comeback will be timely with fellow central defender Anthony Charles set to miss out again with a groin injury he picked up in the 2-0 win at Southend.
Striker Warren Feeney is on the comeback trail after two months on the sidelines with an ankle injury but this match is expected to come too soon for the Northern Ireland international.
Captain Conor Hourihane heads into the clash with their biggest rivals on nine yellow cards, one away from a two-game suspension. And striker Reuben Reid will be involved after his loan deal from Yeovil was extended until the end of the season.
Argyle are now two points clear of the League Two relegation zone having suffered just one defeat in their last six games but they have tasted victory over Exeter just once in the previous five meetings.
Exeter boss Paul Tisdale is confident his promotion-chasing squad can handle two crunch games in just over 48 hours, starting with the Devon derby.
That lunchtime clash on Saturday and Monday's visit of Rochdale will decide whether the Grecians have a realistic chance of making it into the League Two automatic promotion places.
But, injuries and suspensions aside, Tisdale is likely to name a similar line-up in both matches.
Matt Oakley (shoulder), Tommy Doherty (back), Alan Gow and Liam Sercombe (both ankle) are all sidelined but the arrival of Brighton midfielder Anton Rodgers and fellow loanee Lawson D'Ath from Reading have helped fill the void.
John O'Flynn will hope to keep his place after netting in the 4-1 win over Bradford, with top scorer Jamie Cureton pushing for a recall after being an unused substitute against the Bantams.
Cureton has scored 20 goals for the Grecians this season but has failed to net in 12 appearances against the Pilgrims since netting for Bristol Rovers at Home Park in January 1998.