Portsmouth will check on Ricardo Rocha ahead of the visit of the Boro.
The Portuguese defender dropped to the bench for Monday's 1-0 win over Tranmere to rest a hip knock, although he came on for the final few minutes.
Striker Patrick Agyemang will have to sit out as he is on loan from Boro, meaning a rare start for John Akinde alongside David Connolly in attack.
Young winger Jack Maloney could keep his place after a successful full debut against Rovers, meaning Liam Walker starts on the bench again.
Pompey are unbeaten in their last four matches and are now just three points from safety, but still face the prospect of a 10-point deduction when they eventually exit administration.
Stevenage will be without Greg Tansey and Robin Shroot.
Tansey this week underwent an operation on a niggling groin problem which has kept him out of the last couple of matches.
Fellow midfielder Shroot is also facing a spell on the sidelines after he was stretchered off with an ankle injury against Hartlepool on Monday.
Anthony Grant came on for Shroot and could start at Fratton Park, although Gavin Mahon provides another option if he is fit.
Left-back Miguel Comminges returns after a one-match ban but fellow defenders Lee Hills (hamstring) and Jon Ashton (Achilles) are out.
Rookie defender Alex Smith will be hoping to make his debut following his recent loan switch from Fulham.