Argyle manager John Sheridan will be without Conor Hourihane.
The skipper, 22, picked up his 10th yellow card of the season for a mistimed tackle on York's Daniel Parslow in the second half of their 2-0 defeat to Nigel Worthington's men, which means he will miss the Pilgrims' next two matches.
Midfielder Lee Cox is also a doubt for their penultimate home game of the season as he is yet to fully recover from a shoulder injury suffered in the win over Exeter.
Argyle will enter the clash just a point better off than York and two points above bottom side Aldershot after most of the sides around them in the table picked up positive results on Monday.
Russ Penn looks set to return to Cheltenham's starting line-up.
The 27-year-old, who has made 45 appearances for the Robins this season, was rested for the 1-0 win over Northampton and was introduced with a minute to go.
Manager Mark Yates has no fresh injury worries as his side look to close the three-point gap on second-placed Port Vale in the League Two table.
Long-term injury absentee Harry Hooman remains sidelined while Kaid Mohamed and Jason Taylor are pushing for starts.
Sam Deering and Keith Lowe came into the side for the win over the Cobblers and both will hope to keep their places for the clash with relegation-threatened Argyle.