Fleetwood will be without top scorer Jon Parkin for their final League Two home game of the season.
Parkin has been struck down with a chest infection and is taking a prescribed course of antibiotics in the hope of remedying the problem ahead of next weekend's trip to AFC Wimbledon.
Dean Howell has suffered a recurrence of a knee problem, while fellow defender Youl Mawene (foot) remains a long-term absentee.
"The last home game of any season is very important and this is our first in the Football League," said boss Graham Alexander on the Cod Army's official website.
"The players must show the same improved level of commitment and spirit as they did at Rotherham. That in turn gives the supporters a voice and the players then respond.
"We have the potential for a fantastic atmosphere on Saturday. As a club we can look back on many achievements this season and look forward to a second Football League campaign. There is plenty to be optimistic about."
Chesterfield will check on veteran striker Jack Lester ahead of their first visit to Highbury.
Lester missed out with a back problem in midweek as former manager John Sheridan returned to the Proact Stadium with Plymouth and won 2-1 to deal a severe blow to the Spireites' hopes of reaching the play-offs.
Blues boss Paul Cook delivered a scathing attack on his team following the defeat on Tuesday night, accusing them of failing to turn up for what was the biggest game of the season so far.
Substitutes Alex Henshall, Armand Gnanduillet and Sam Hird will be hoping to start after they helped to improve what had been a dire performance against Argyle.
Danny Whitaker should also be in the frame for a recall after missing that game due to family reasons while fellow midfielder Craig Clay and striker Scott Boden are also options for Cook.
Chesterfield need to win on Saturday and beat Exeter at home on the final day of the season and hope Bradford get no more than two points from their remaining two matches if they are to gatecrash the play-offs.