Tranmere boss Ronnie Moore has promised to field an attacking line-up.
Rovers have not scored a goal in their last five games - which have all ended in 1-0 defeats - and have seen their play-off hopes disappear.
But the manager wants his side to give the Cherries a real fight, as the visitors look for the win that will secure the championship.
"I'm going to play one or two more attack-minded players and have a real good go for it," he told the club's official website.
"It's one you want to win for pride. You've got to finish right, you can't just throw three kids in there, you've got to be professional."
Abdulai Bell-Baggie could return in attack after dropping to the bench against Preston but club captain James Wallace (knee) and winger Adam McGurk (hip) remain sidelined.
Bournemouth have no fresh injury worries as they look to clinch the league title.
The 3-1 victory over Carlisle last weekend sent the Cherries into the Championship for just the second time in their history and manager Eddie Howe is unlikely to shuffle his pack as they target the title which three points at Prenton Park would secure.
And if they do pick up the win it would be their ninth successive victory, having conceded just three goals in their previous eight straight wins.
Only long-term injury absentees Miles Addison, Stephen Purches and Stephane Zubar are unavailable for the Cherries and Howe looks likely to name the same squad once more.
Shaun MacDonald and Richard Hughes stepped off the bench at the Goldsands last weekend and the duo will be pushing for starts in what looks set to be a memorable afternoon for followers of the Cherries.