Accrington have no new injury problems for the final game of the campaign.
Leam Richardson's men secured survival with a 1-0 win against Bristol Rovers last time out and are targeting a third win on the bounce.
It would be the first time this campaign Stanley had achieved the feat and Richardson has a full squad at his disposal.
Francis Jeffers made his return from a hamstring injury as a second-half substitute at the weekend and could be in line for a start to end the campaign.
Defender Nicky Hunt is also pushing for some game time after being an unused substitute in the last two games after overcoming a hamstring problem of his own.
Stanley are on a five-match unbeaten run and could leapfrog Morecambe and end the year in 16th with a victory.
Oxford's Tyrone Marsh will be involved in the U's final match of the season.
The striker, 19, has been recalled from a loan spell at Staines Town where the Oxford youth product had netted nine times in 16 games as he helped steer the side away from relegation danger.
And after featuring in their 2-0 defeat to Dover on Tuesday night, Marsh, who scored his first senior goal for the club against Southend earlier this season, was recalled by manager Chris Wilder who ended speculation over his own future at the Kassam on Friday by signing a new 12-month deal.
Oxford ran out 3-0 winners against Rochdale last time out and will look to end an ultimately frustrating season with victory against Stanley. They were without captain Jake Wright in that match and the defender is a doubt for the trip.
Sean Rigg and Michael Raynes returned to the starting line-up against Dale and they will hope to keep their place, while James Constable staked his claim for a place in the XI after scoring following his introduction at half time.
Youngsters Callum O'Dowd and Sam Long are expected to be involved once more as the U's look towards the 2013/14 League Two campaign.