Graham Westley left the Deepdale dugout to a standing ovation after his new-look North End saw off the Terriers.
Westley endured a troubled time after taking over at Preston last season but saw his side make the perfect start to the new campaign when Jack King headed home after 29 minutes.
Nicky Wroe, a summer signing from Shrewsbury, then doubled the lead five minutes before the break to help the League One side into the next round.
Westley fielded a starting 11 which featured 10 summer signings, with only goalkeeper Thorsten Stuckmann surviving the summer cull.
And the North End new boys enjoyed a dream start to the season when King's deft header floated past Alex Smithies in the Huddersfield goal after 29 minutes.
The striker, signed from Woking in the summer, directing Jeffrey Monakana's brilliant chipped ball inside the far post.
Wroe then side-footed Chris Beardsley's low cross into a gaping net five minutes before half-time to double the advantage.
Lee Novak would have pulled a goal back for the visitors after the restart had he not been tardy to Paul Dixon's cross.
Seconds later, Oscar Gobern's meek effort wasted some fluid build-up play as the Championship side failed to make their league supremacy count.