The final whistle goes and West Brom have run out 2-0 winners to climb into fifth place in the Premier League and leave Southampton bottom.
Three minutes of stoppage time are to be played, as West Brom sit back and protect their lead.
Another corner yields a chance for Southampton as Maya Yoshida rises highest in the area, but his powerful downward header flies wide of the post.
Southampton win a corner and throw all their big men forward, but it is a familiar tale as once again it is a West Brom head that is first to the ball.
Southampton have certainly not thrown in the towel here and are continuing to fight hard in an effort to get something from the game, but at the moment West Brom still look secure.
Peter Odemwingie shows his appreciation to the crowd as they clap him off, with Marc-Antoine Fortune replacing the two-goal star for the closing stages.
Southampton's third and final change sees 17-year-old Luke Shaw come on for his Premier League debut in place of Danny Fox.
Southampton's players appeal for a penalty as Adam Lallana goes down in the box under pressure from Jonas Olsson. Replays suggest Saints had a case for a spot-kick, although Lallana himself did not make much of it.
West Brom's two substitutes nearly combine to devastating effect as Romelu Lukaku shows good strength to win the ball and then delivers a cross to the back post, where Chris Brunt's well-struck first-time volley is lashed back across goal and narrowly wide.
Guly has an opportunity to make an immediate impact but gets his header all wrong and the ball loops up and goes harmlessly out of play.
Nigel Adkins opts to make a double change with a quarter f an hour remaining, bringing on Emmanuel Mayuka and Guly for Jay Rodriguez and Gaston Ramirez.
Southampton win a corner but it again comes to nothing and West Brom spring forward on the break.
The introduction of Romelu Lukaku will pose a different sort of threat to Southampton, although he is unable to hold the ball up here as a stray pass goes straight out of play.
Shane Long receives a good round of applause as he goes off to be replaced by on-loan striker Romelu Lukaku for the final 20 minutes.
Shane Long fails to spot an opportunity to play in Zoltan Gera and dwells on the ball for too long as Southampton are briefly outnumbered at the back.
Southampton have had the majority of possession but have not done enough with the ball and it will be tough now to break down this resilient West Brom defence.
Chris Brunt, only just fit again following injury, comes on for Graham Dorrans as Steve Clarke makes his first substitution of the night.
Gareth McAuley beats his defender in the air but sends his header over the crossbar from a corner as West Brom continue to dominate.
Shane Long does well to burst away down the left wing but Nathaniel Clyne is quick enough to catch up and slides in with a well-timed challenge to concede a corner.
Southampton earn a free-kick in a menacing area out on the left wing but West Brom look so much more organised in defence and now have a two-goal cushion to protect so they will be in no rush to commit many men forward.
GOAL Peter Odemwingie heads in a second for West Brom from Shane Long's delightful cross, as Southampton are caught out by a fast counter-attack.
West Brom set up camp in the Southampton half as they win a free-kick and then a corner, which Saints struggle to defend before Jonas Olsson fouls Jose Fonte.
Nathaniel Clyne shows some ambition with a run down the right before the ball switches to the other flank, where Danny Fox's final ball is not good enough and Ben Foster cuts it out.
Peter Odemwingie takes too long in sending over a cross from the right and when he finally delivers it is misplaced, sailing over the head of Shane Long and out of play.
The game is bogged down in midfield just at the moment as both sides try to gain control with a series of strong tackles.
Ben Foster has to be alert to rush off his line and claim the ball before Gaston Ramirez can latch on to a clever pass from Jay Rodriguez.
West Brom push forward through Billy Jones down the right and his cross is well cleared by Nathaniel Clyne.
If Southampton were already feeling that luck was not on their side, then they are unlikely to have changed their minds now as Rickie Lambert crashes a shot against the crossbar after West Brom fail to deal with a cross.
Southampton enjoy a spell of passing in midfield at the start of the second period as West Brom sit back and look to counter That could be the pattern for the rest of the game.
West Brom get the second half started. There have been no changes at the interval but the onus will be on Southampton to try and find an equaliser.
The half-time whistle goes and it is West Brom who lead 1-0 thanks to Peter Odemwingie's effort. It is has been an absorbing first 45 minutes and Southampton must feel like they can get back into this one after the interval.
Paulo Gazzaniga denies Shane Long from point-blank range as West Brom seek a second before half-time. Peter Odemwingie seizes on the rebound and appeals for handball as his shot crashes into Morgan Schneiderlin, but the Southampton player's arms were not raised and it is the correct call not to award a penalty.
Adam Lallana skips forward down the left as Southampton launch a swift counter-attack, but he is unable to pick out a team-mate in the centre as Billy Jones shows good discipline to stay with him and concede a corner. From the set-piece, Ben Foster tries to come through a sea of bodies to make the catch and drops the ball. He gathers it again quickly, but he has to be thankful for a lucky bounce.
Youssouf Mulumbu takes aim with a shot from distance following Shane Long's knockdown, and it is deflected wide for a West Brom corner.
Southampton have responded well since falling behind but their final ball has not been good enough so far today, as Ben Foster again intercepts a cross with ease.
Southampton will feel hard done by at conceding the opening goal to an unlucky deflection, while they also felt there was a handball from Peter Odemwingie in the build-up.
GOAL Peter Odemwingie opens the scoring for West Brom with a powerful shot from 25 yards that takes a crucial nick off Maya Yoshida on its way past Paulo Gazzaniga.
Peter Odemwingie is not afraid to let fly from distance but on this occasion he probably wishes he hadn't bothered, as he slices a shot so far wide it threatens the corner flag and amuses the visiting fans.
Paulo Gazzaniga has to scramble anxiously down to his left as a low Peter Odemwingie shot from 25 yards fizzes inches wide of the post. Not sure if the keeper would have saved that if it had been creeping in.
Rickie Lambert is presented with a chance for Southampton as a cross comes in, but his header is tame and drops safely into the arms of Ben Foster.
Southampton relieve the pressure with a counter-attack and nearly get lucky as Adam Lallana's attempted cross ricochets off a defender and flies narrowly wide of the far post.
Southampton are being given a good aerial test at the moment as West Brom win a couple of corners in quick succession, but Paulo Gazzaniga keeps control of his area with a strong palm to one delivery and then a catch off the next.
West Brom are enjoying a good period here, as Jonas Olsson wins the ball in the air from a good free-kick but Shane Long is just unable to turn it in before it drifts out.
Youssouf Mulumbu again tries to release Shane Long, this time with a long pass right out of defence, but it is just too heavy and runs on for Paulo Gazzaniga to collect.
Shane Long hangs his head in frustration after squandering another good chance for the Baggies. The striker was played in by Youssouf Mulumbu after Gaston Ramirez had been caught napping in midfield, and his attempt to curl a shot into the top corner went horribly wrong as the ball floated harmlessly high and wide.
This time Peter Odemwingie comes back inside when faced with Danny Fox and drives a dangerous cross-cum-shot into the area which Zoltan Gera side-foots off target with a first-time effort. He was in the middle of the box and that is the best chance of the game so far that has gone begging.
Peter Odemwingie tries to beat Danny Fox just outside the area on the right but the Southampton full-back makes a decent tackle.
Southampton are seeing plenty of the ball during the early stages and so far have not been seriously threatened at the back, so Nigel Adkins will be satisfied at this point.
Ben Foster is called into action as he makes a smart stop from Rickie Lambert's shot. It is from a tight angle and more or less straight at the keeper, but it was very firmly struck.
Shane Long shows good movement up front as Peter Odemwingie tries to play him in on goal, but the ball just takes a slight deflection off a defender and the attack fizzles out.
Jay Rodriguez sends Gareth McAuley tumbling as he slides in with a strong challenge, with looked to be mistimed and he is perhaps fortunate to escape a booking.
Adam Lallana wins a free-kick for Southampton in a dangerous area after cleverly spinning away from Jonas Olsson, but Gaston Ramirez's effort crashes into the defensive wall.
Billy Jones receives an early caution from referee Mark Halsey following a high tackle on Adam Lallana, and he will now have to be very careful for the rest of the match.
Ben Foster is again given some catching practice as Rickie Lambert delivers a wayward cross which is far too easy for the West Brom keeper to deal with.
Southampton win a free-kick just inside the West Brom half and Danny Fox sends in a high ball that is comfortably claimed by Ben Foster.
Billy Jones finds himself in space down the right wing but his cross is disappointing and West Brom are slightly fortunate that Southampton cannot clear their lines convincingly and concede a corner moments later.
West Brom enjoy a spell of possession in midfield as they strive to take a firm grip on the game and exert some pressure on the visiting team.
The ball drops to Steven Davis on the edge of the West Brom area but he cannot keep his shot down and the ball flies high into the stands.
The two teams have lined up very differently, as expected, with West Brom favouring a 4-2-3-1 formation and Southampton looking like a more traditional 4-4-2.
Morgan Schneiderlin gets back to make a fine covering tackle on Shane Long after a slip by Maya Yoshida had presented West Brom with an early opportunity.
Southampton get the match started and let us hope for an open encounter with plenty of goals.
Russell says: "A mistake by Clarke to include four rusty legs in Yacob and Long, and not to give the two hottest ones in Lukaku a go, who could pick off the Saints D. Saints one foot in the door."
So Southampton have decided to axe Artur Boruc and bring in Paulo Gazzaniga between the posts, while record signing Gaston Ramirez is back from a five-week absence with a thigh injury. For West Brom, defender Billy Jones and midfielder Claudio Yacob return after injury, with Gabriel Tamas making way and James Morrison injured. Shane Long gets the nod over Romelu Lukaku up front.
Nigel Adkins on Gaston Ramirez: "We need to get him and Adam Lallana on the football and if we can do that we will give ourselves an opportunity to feed Jay Rodriguez and Rickie Lambert, who are two phenomenal strikers in my eyes."
Alex is the first to get in touch, saying: "Another goalkeeper change and Ramirez back in the team. It's a gamble Adkins needs to pay off. Up the Saints."
Steve Clarke has been speaking on TV ahead of the game, admitting it was a difficult decision to select Shane Long ahead of Romelu Lukaku up front for tonight's game and praising his central midfielders.
West Brom: Foster, Jones, McAuley, Olsson, Ridgewell, Mulumbu, Yacob, Odemwingie, Gera, Dorrans, Long. Subs: Myhill, Popov, Rosenberg, Brunt, Lukaku, Tamas, Fortune.
Southampton: Gazzaniga, Clyne, Fonte, Yoshida, Fox, Schneiderlin, S Davis, Lallana, Ramirez, Lambert, Rodriguez. Subs: K Davis, Hooiveld, Ward-Prowse, Guly, Shaw, Mayuka, Puncheon.
This just in from our friends at Sky Bet: Punters are piling into West Brom ahead of tonight's Premier League clash with bottom club Southampton. More than 80 per cent of bets placed so far are on the Baggies (8/11) to take all three points. There is some hope for Southampton fans as West Brom have never won a televised MNF match and they are 7/2 to spring a surprise. While Shane Long has scored the opening goal three times for the Baggies this season it's Romelu Lukaku who is proving popular in the first scorer market - both men can be backed at 5/1 to net first.
Do you think West Brom will return to winning ways tonight and move into the top six, or can Southampton pull off an away win to climb off the foot of the table? Get in touch with your views and predictions at Lewis.Rutledge@bskyb.com or via Twitter @SkySportsLewis. The full team news will be in shortly but who do you think are likely to be the key players?
Good evening and welcome to our minute-by-minute commentary of West Bromwich Albion's Premier League game against Southampton at The Hawthorns. The two teams have had contrasting starts to the season, with the Baggies looking solid in the top half of the table despite losing their two most recent matches. Nigel Adkins' Saints, meanwhile, have slipped to the bottom of the standings following the rest of the weekend's results and have the worst defensive record at this stage in Premier League history, having conceded 26 goals in their opening nine games.