Stay with us for a comprehensive match report and all the key reaction from Roberto Mancini and Roberto Martinez.
All over at the DW Stadium and Man City take the spoils.
Stam makes way for Callum McManaman.
Di Santo does well to wriggle free on the byline and cross, with Gomez and Zabaleta tangling in the area and in some pain.
Lazy backpass from Balotelli briefly interests Kone, but Hart is alive to the danger and clears.
Three additional minutes will be played, and we're already well into the first of those.
Now Balotelli feeds the on-rushing Toure, who earns a corner.
Zabaleta makes an excellent run but is ignored by Silva, who instead finds Kolarov out on the left, but his cross is too hard for the City attackers.
Full-time is rapidly approaching now and there looks to be no way back for Wigan.
Lopez is penalised for a challenge on Yaya Toure near the halfway line.
Nastasic has to be alert to deny Kone at the near post.
Tough luck on James Milner, as his goalscoring cameo is ended by injury. Kolo Toure comes on.
Toure rampages forward and exchanges passes with Silva before driving a shot well over the bar.
Maicon probably should have made it 3-0 there, but he fires wide after racing onto Boyce's attempted clearance.
If you're keen on in-play betting, Sky Bet say: City look to have wrapped things up in the space of three second-half minutes, and Sky Bet go 8/11 for there to be no more goals in this one.
This scoreline is a touch harsh on Wigan, who have more than matched Man City for long periods. But this is why one of these sides will be battling for the title, while the other is more likely to be scrapping against relegation.
David Jones makes way for James McArthur.
Absolute peach of a finish from James Milner, unleashing an unstoppable effort from the edge of the box into the top corner after being found by Gareth Barry.
GOAL!!! SCREAMER FROM JAMES MILNER.
Wigan look for an instant response and Hart has to be alert to push away Jones' free-kick.
Barry's shot from the edge of the box is fumbled by Al Habsi, with the keeper almost making amends as he keeps out Balotelli's first effort, but the Italian striker gobbles up the rebound to lash home.
GOAL FOR MAN CITY - MARIO BALOTELLI!!!
Second change for City, and a bit of a surprise, with Kolarov coming on for Aguero.
Maicon's cross towards Balotelli brings an attempted overhead kick from the Italian, but he only succeeds in catching Boyce.
Good play from Aguero, jinking away from one challenge to make his way into the Wigan box before his attempted cross is too deep for Balotelli.
Jones flights in a good kick which is heading for the far post and Di Santo before Hart gets an important hand to the ball.
Corner for Wigan after good work from Kone and Stam.
Barry goes into the book for a late challenge on Gomez. Obvious yellow card.
Nice play from Wigan as Beausejour flights a dangerous ball into the box which is ahead of Kone at the near post and just beats Gomez at the far.
Mancini makes his first change with the ineffective Javi Garcia replaced by James Milner.
Wigan have the chance to break as Jones feeds Di Santo, but he cannot outwit Nastasic.
Now a glorious chance for Wigan. Shocking header from Kone who is 10 yards out and in acres of space but he can only head McCarthy's pin-point header woefully wide.
Beausejour attempts to cross from the right but Nastasic clears away.
Glorious chance for Balotelli at the far post from Maicon's cross, but he inexplicably heads wide of the target. Really should have scored there.
Toure's cross into the far post is too strong for Barry, with the City midfielder fuming as he feels Stam was pulling his shirt. Replays show he had a very strong case.
Balotelli takes the free-kick, but it loops up off the wall. Toure gets his head to it and finds Barry, but his touch towards Zabaleta is cleared away by the home defence.
Balotelli is upended by Lopez on the edge of the area.
Silva fires in a shot from the edge of the area after finding a yard of space but the effort is straight to Al Habsi.
Balotelli shoots from the centre circle, but is closer to the corner flag than the goal.
We're back for the second half. No changes from either side and City get us under way again.
A half-time message from our friends at Sky Bet: Although the Latics are still level at the break, Sky Bet offer odds of 7/1 that they can pull off a win. City remain 8/11 favourites, with a draw available at 13/8. If Wigan are to win, you sense it may only take a single goal, with a 1-0 home win rated at 12/1. Of the next goalscorer market, David Silva is a popular choice at 9/1.
Halsey brings an entertaining, but goalless, first half to a close.
Chance for City on the stroke of half-time as Toure tricks his way into the box before driving a low shot straight at Al Habsi from a tight angle.
Now Gomez goes into the book for a nasty, late, sliding challenge on Barry.
Gomez goes down on the edge of the Man City penalty area as he looks to get away from Zabaleta, but Mark Halsey is not interested. Looked a penalty to me.
Two additional minutes will be played.
Di Santo bursts from his own half deep into City territory. He is short on options so unleashes a shot which deflects behind for a corner.
The ball is clipped into a decent area at the far post, but there are no City shirts attacking it. The visitors keep the pressure on and earn a corner, which Al Habsi and Gomez combine to clear downfield.
Balotelli earns a free-kick after tangling with Beausejour near the touchline. Silva to take.
Javi Garcia finds Maicon with a great long-range pass, but his lay-off towards Balotelli is intercepted by Figueroa.
Toure is penalised for pulling back Jones on the edge of the Wigan box.
Gomez takes responsibility and curls a decent effort up and over the wall. Joe Hart is diving to cover his top corner, but the ball misses the target and takes out the camera behind the goal.
Aguero brings down Gomez to give Wigan a free-kick in a good central position just over 25 yards out.
Jeers from the home fans as Balotelli attempts to flick the ball forward, but succeeds only in falling on his backside.
More great play from Stam as he roasts Zabaleta down the right flank. He almost over-runs the ball but manages to cross for Kone, who heads narrowly over the bar at the near post.
Scrappy spell of play, with both teams giving the ball away in midfield far too cheaply.
Another Man City corner, this time taken by Balotelli from out on the left, is fisted away powerfully by Al Habsi.
City clear the corner and Figueroa makes a hash of his header, allowing Aguero - who seems swiftly better - to race in on goal, but Lopez is across to cover.
Another chance for Stam to cross and he forces Maicon to concede a corner. Worry for City, with Aguero in some discomfort after colliding with the advertising hoardings.
Corner to City as Maicon gets away from Beausejour but Figueroa is across to clear. Silva's kick comes to nothing.
City completely over-play the free-kick, with Aguero passing to Silva, who feeds Barry, whose dinked ball into the box is headed away. Too clever by half and not effective in any way.
Stam fells Balotelli out on the left on the corner of the penalty area to give City a free-kick in an interesting position.
Hart gathers a Beausejour cross cleanly and immediately releases Silva. He passes forward towards Balotelli, but Lopez gets an important foot to the ball before Al Habsi is off his line to claim at the striker's feet.
Aguero tries a snap-shot from outside the area, but fails to connect cleanly and pulls his shot wide of Al Habsi's goal.
Yaya Toure attempts to thread a pass through to Balotelli, and while the pass is accurate, it is a bit too strong and flicks off a Wigan boot before going out for a corner, which Al Habsi gathers cleanly.
Man City are looking to work an opening out on the left flank, but Aguero, Silva and Toure dally too long, allowing the Wigan defence to push out, with the flag going up for offside.
Gomez feeds Beausejour, who cuts inside and attempts a shot with the outside of his boot which is blocked by the diving Kompany. Decent chance.
Di Santo wants a free-kick as he feels his run is blocked by Kompany, but referee Halsey is not interested.
Great skill from Stam to create space for himself out on the right wing, bamboozling Zabaleta with a drop of his shoulder, before producing one of the worst crosses you are ever likely to see, which flies straight out of play.
Maicon is back on the field and the game continues.
Looks like Maicon is OK and should be able to continue. Di Santo initially played on, which was fair enough given it wasn't immediately apparent what the problem was.
Maicon is down and in some distress after taking a ball in the throat from Di Santo. Mark Halsey swiftly stops the game to he can receive treatment.
Aguero and Zabaleta combine on the left of the Wigan box, but the defender's surge is stopped by a well-timed tackle from McCarthy.
Another chance for Man City as Silva releases Aguero into the Wigan half. He is allowed to make his way into the area before firing a powerful shot into the side-netting. Decent, open, start to this game.
Gomez and Beausejour combine down the left flank but the latter's cross is too heavy for Stam at the far post. Maicon was caught out very easily, there.
Acres of space for full-back Maicon down the right flank again and he lashes in a shot from a tight angle which whistles over the angle of Al Habsi's goal.
Gareth Barry attempts a clever flick and only succeeds in giving the ball to Di Santo. He bursts into the City half and feeds Kone, who drills a low shot at Hart, who gathers at the second attempt.
Early chance for Maicon to advance after being found by David Silva and he whips over a great cross to the far post which is beyond Al Habsi, but also too strong for Aguero.
Early touch for Balotelli after a pass from Aguero, but he slips as he looks to advance and the Wigan defence clear downfield.
Referee Mark Halsey blows his whistle and Wigan get the contest under way.
Pre-match huddle from the Wigan players.
Roberto Mancini and Roberto Martinez finally emerge from the dressing rooms to take their seats on the bench.
Pre-match handshakes, with City in their rather unpleasant away kit. Plum? Aubergine? Maroon?
The two teams are in the tunnel and ready to make their way out onto the DW Stadium surface.
Wigan have made two enforced changes as Adrian Lopez and Franco di Santo come in for Shaun Maloney and Ivan Ramis.
Dave Silcock, from Stratford, Canada, writes: "I am looking for a bit of an upset tonight, with a weakened Latics pulling off a 1-1 tie. Goals from Aguero and Kone." 1-1 tie? Someone has been the wrong side of the Atlantic for too long....
While we're on with the predictions, I can't see anything other than a win for Man City tonight and will go for a 3-1 victory for Roberto Mancini's men. Disclaimer: I am very bad at predicting scores and now let my six-year-old look after my Super 6 account.
Ian Ashman has been in touch from Mallorca to say: "I can see the mighty Blues continue on their unbeaten run tonight. I would rather have Tevez up front with Kun, than wildcard Mario. City to grind this one out 2-0. Scorers: Yaya is due one and Kun the other."
There's a host of markets on offer from our friends at Sky Bet for tonight's game. Here are some of their highlights. Champions Manchester City are 4/9 on to take a win away from 6/1 underdogs Wigan tonight, with the draw available to back at 7/2. City came to the DW Stadium last year and ground out a 1-0 win, and a repeat scoreline is available with Sky Bet at 7/1. Edin Dzeko scored the goal on that occasion, and he's 4/1 to score the last goal tonight. Last weekend's hat-trick hero Jordi Gomez is 11/1 to continue his exploits for Wigan as first goalscorer, while back-to-back hat-tricks for the Spaniard is a long shot at 150/1. Sergio Aguero has received the most backing for first goalscorer at 3/1, while plenty of punters fancy Vincent Kompany to break the deadlock at 25/1.
Just a reminder that it is an 8pm kick-off for tonight's clash at the DW Stadium.
Twitter input from @jackashurst2, who writes: "I think that if Wigan pull themselves together today there is a very good chance of an upset, Wigan to win for me 2-1."
Man City: Hart, Zabaleta, Maicon, Kompany, Nastasic, Silva, Yaya Toure, Barry, Garcia, Aguero, Balotelli. Subs: Pantilimon, Milner, Dzeko, Sinclair, Kolarov, K Toure, Tevez.
Wigan: Al Habsi, Boyce, Figueroa, Stam, Lopez, McCarthy, Jones, Beausejour, Gomez, Kone, Di Santo. Subs: Pollitt, McManaman, McArthur, Boselli, Fyvie, Golobart, Redmond.
Cian Hughes is first to get in touch and writes: "Wigan have been very good this season, I think, and if they pull together and try to put in a team effort, then they might have a chance. But it's Manchester City, for me, 3-1 Man City."
Opta stat No.5: Wigan have conceded more penalties than any other Premier League side this season (4).
Opta stat No.4: If City avoid defeat in this game they will match their unbeaten start of 14 games from last season. Only two teams (Arsenal twice and Man Utd) have gone on longer unbeaten runs at the start of a Premier League season.
Opta stat No.3: City have drawn four of their last six Premier League away games, the last two ending 0-0.
Opta stat No.2: Carlos Tevez has scored four goals in five Premier League games for Man City against Wigan.
Opta stat No.1: Manchester City have won six and lost none of their last seven Premier League games against Wigan. In that run of seven games, Wigan have netted only one goal and failed to score in the last five in a row.
Here's a couple of statistics from our friends at Opta for you to mull ahead of the action.
If you want to get in touch and have your say on this evening's game, then drop me a line to email@example.com or via Twitter @skysportsrobp and I'll publish a selection of the best prior to kick-off.
Good evening and welcome to our live and interactive commentary on tonight's clash from the DW Stadium.
Kick-off is 2000 GMT.