Captain Patrice Evra, Rio Ferdinand, Robin van Persie, Wayne Rooney, Paul Scholes, Ryan Giggs and David de Gea have all not travelled to Turkey.
Of the more experienced members of the United squad, Michael Carrick and Darren Fletcher are included, as are strike duo Danny Welbeck and Javier Hernandez.
It means Sir Alex Ferguson's team will have a strong infusion of youth, including Nick Powell, while Josh King, Davide Petrucci, Tom Thorpe and Ryan Tunnicliffe are among those hopeful of having some involvement in the Champions League for the first time.
Galatasaray boss Fatih Terim has vowed to make 'two changes' to his starting XI, following a 3-1 reversal against Kardemir Karabukspor on Friday.
He has, however, stopped short of revealing the identity of those set to be drafted in and out of his plans.
Gala have a virtually fully-fit squad from which to select, with Tomas Ujfalusi their only long-term absentee.
Aydin Yilmaz is a slight doubt heading into the game, as he is struggling with a bout of flu, but Terim claims he will be available 'if needed'.