Striker Emmanuel Adebayor will miss the game as he has still not recovered from a hamstring injury.
Brad Friedel has not travelled to Athens, meaning either Hugo Lloris or Carlo Cudicini will start in goal.
Jake Livermore (groin), Younes Kaboul (knee), Kyle Naughton (foot), Scott Parker (Achilles) and Benoit Assou-Ekotto (knee) are out.
Tottenham (from): Lloris, Cudicini, Smith, Vertonghen, Gallas, Dawson, Caulker, Walker, Dempsey, Huddlestone, Lennon, Bale, Dembele, Sigurdsson, Falque, Townsend, Sandro, Mason, Defoe.
