The side will not be a second string like the team which lost to Anzhi Makhachkala in Moscow a fortnight ago, which means the likes of Steven Gerrard and Luis Suarez could feature at some stage.
Midfielder Lucas Leiva is still not fully fit as he nurses his way back from the thigh injury which has kept him sidelined since August, and the Brazilian will play for the U21s on Friday as he steps up his rehabilitation.
Young Boys are set to be without Canadian winger Josh Simpson, who suffered a broken leg back in May.
Venezuelan forward Joseph Martinez and goalkeeper Ivan Benito are also missing as they struggle with thigh complaints.
Left-back Christophe Spycher (knee) and centre-half Jan Lecjaks (foot) may play some part at Anfield, but both are rated at 50-50 heading into the continental clash.