Coventry welcome back leading goalscorer David McGoldrick and midfielder James Bailey for their JPT clash with the Blades.
The on-loan pair have both been denied permission to feature in the FA Cup by respective parent clubs Nottingham Forest and Derby and so missed Saturday's 2-1 win over Morecambe.
But they return to contention against the Blades as Mark Robins' side aim to move one step closer to Wembley.
Chris Dunn stepped in for first-choice goalkeeper Joe Murphy at the weekend as he rested a shoulder problem but the former Scunthorpe stopper trained on Monday and comes back into the frame.
And Robins, who boasts no new injury or suspension concerns, is likely to send out a strong XI for the encounter and not make too many changes.
"I'll field a side who I think will help us progress," he said. "I think Danny (Wilson, Sheffield United boss) will do the same.
"We're in it to try and win the game and pick a side who's going to go on and do it in the right way, play in the right way.
"You only get one chance at the cup competitions and this one goes immediately to penalties, so we want to be getting through and going as far as we possibly can in the competitions we're in."
Sheffield United midfielder Kevin McDonald returns to contention following suspension.
McDonald sat out the FA Cup win over Port Vale at the weekend after reaching five yellow cards, but is expected to return to the starting line-up.
Manager Danny Wilson has no major new injury or suspension worries, but several unspecified players are nursing bumps and bruises and there could be changes for the northern section quarter-final.
Winger Jordan Chapell has been recalled from his loan spell at Burton and could feature for the Blades, while forwards Richard Cresswell and John Cofie are both hoping for recalls.
Striker Dave Kitson is unlikely to be involved as he recovers from the hamstring problem that has kept him out for the last eight matches, while goalkeeper Mark Howard (thigh) and defender Tony McMahon (hamstring) remain sidelined.