Yeovil will be without cup-tied duo Paddy Madden and Dale Bennett as they have already played for Carlisle and AFC Wimbledon respectively in the competition.
Top scorer Madden missed the defeat to parent club Carlisle last time out due to the terms of his loan deal and was replaced by Gozie Ugwu and the Reading loanee could get the nod again up front while Watford defender Bennett will miss out on the chance of a first Glovers start.
Captain Jamie McAllister is also available again after serving a one-match ban against the Cumbrians and could step straight back into Gary Johnson's starting XI against their League Two visitors.
Lewis Young and Nathan Ralph remain sidelined for a few more weeks while midfielder Dominic Blizzard is still out with a groin injury.
Wycombe boss Gareth Ainsworth will be without two midfielders.
Josh Scowen and Stuart Lewis both picked up their fifth bookings of the campaign in Saturday's 2-0 victory against Bristol Rovers but it means they'll both miss out as Wycombe look to win at Huish Park for the first time in their history.
Joel Grant, the club's top scorer who netted his fourth goal in his last five games in the Chairboys' win against Rovers, will be assessed in the build up to kick-off having been withdrawn at half-time with double vision after a blow to the head.
Ainsworth brought himself on for Grant at the interval and went on to score the second goal and the player-manager may name himself in the starting XI if the 25-year-old is ruled out.
This game will come too soon for injured trio Danny Foster, (knee) Anthony Stewart (thigh) and Gary Doherty (back) who are all set to return to training in the coming days.