Brighton will be without Spanish trio Bruno, Andrea Orlandi and Vicente when they host Millwall.
Defender Bruno missed Saturday's goalless draw against Nottingham Forest with an Achilles injury and has been ruled out again.
His countryman Inigo Calderon is set to deputise at right-back once more despite picking up a knee knock at the weekend.
Orlandi is recovering from a broken rib and fellow midfielder Vicente remains sidelined due to a thigh problem, with both likely to be out until the new year.
Gary Dicker is still struggling with the knee injury he suffered in training last week and the midfielder is likely to miss out again.
Boss Gus Poyet could therefore name an unchanged side as they look for a first win in four matches.
Millwall will be without Jimmy Abdou when they head to Brighton.
The midfielder serves a one-match ban after picking up his fifth yellow card of the season in the 1-0 win over Leicester on Saturday.
Josh Wright could be handed a recall in Abdou's absence while winger Chris Taylor may have earned a start after climbing off the bench to hit the winner against the Foxes.
Darius Henderson is close to being fit after a hamstring injury but the seven-goal striker is not expected to be risked at The Amex.
Skipper Paul Robinson remains on the sidelines as he continues his recovery from a pelvic problem, and young forward John Marquis is the only other absentee following a groin operation.