Pilgrims manager Carl Fletcher will be without suspended midfielder Conor Hourihane.
The 21-year-old Irishman was sent off during Saturday's 1-0 loss to non-league Dorchester in the first round of the FA Cup.
His suspension means that Jamie Lowry, still recovering from a long-term injury, will continue in Fletcher's side.
He told Plymouth's official website: "Jamie Lowry, he's going to have to play again Wednesday. We played him (against Dorchester) because Youngy (Luke Young) had four bookings and we didn't want to lose him. We'll make sure we recover right and we'll go again."
Plymouth are without a win in their last three matches in all competitions and currently sit 18th in League Two.
Burton manager Gary Rowett could welcome duo Marcus Holness and Chris Palmer back into the starting XI.
Central defender Holness (hamstring) and midfielder Palmer (Achilles/calf) were both unused substitutes during Burton's 3-3 draw with Altrincham in the FA Cup on Sunday.
Brewers skipper John McGrath, who has spent eight months on the sidelines with torn foot ligaments, looks set to miss out once more but is close to making a return to first-team action.
Defender Aaron Webster will not feature as he is still nursing a hamstring problem, while the game looks to have come too soon for striker Adi Yussuf, who remains sidelined with a groin injury he sustained in training last month.