Dons manager Karl Robinson will give late fitness tests to Daniel Powell and Luke Chadwick
Chadwick, who limped off in the dying minutes of Friday night's FA Cup tie against Cambridge City, did not train on Monday and will be assessed along with Powell.
The Dons, who are chasing back-to-back league wins, will be boosted by the return of strikers Dean Bowditch and Charlie MacDonald.
Bowditch is expected to feature after he resumed training following a knock that has kept him out of the previous four games, while MacDonald is also back having recovered from an illness that saw him miss the trip to Cambridgeshire last week.
Loanee Angelo Balanta is also available for selection.
Leyton boss Russell Slade could welcome back Scott Cuthbert and Kevin Lisbie
Defender Cuthbert and striker Lisbie both made their return to training after making full recoveries from hamstring injuries.
Cuthbert had been on the treatment table since August 18 while Lisbie has not appeared for Orient since October 6.
Meanwhile Slade has a selection dilemma in goal. First choice goalkeeper Jamie Jones is vying for a place in the starting line-up after recovering from a shoulder problem but youngster Ryan Allsopp will be hoping to keep his place between the sticks.
The O's go into this clash off the back of three defeats that have seen them fall to 19th in League One.