Oxford are expected to name influential striker Alfie Potter in their line-up.
The forward, 23, was substituted by manager Chris Wilder in the 61st minute against Aldershot after he picked up a slight knock. Wilder withdrew him as a precautionary measure and is confident he will be fine to face Stanley.
But Wilder will be without Simon Heslop as he serves the first of a three-game ban for his red card against the Shots. Oxford's appeal against the decision was rejected on Tuesday meaning the midfielder will miss out.
Jon-Paul Pittman (shoulder) and Andy Whing (knee and ankle) will not feature with injuries they picked up during the dramatic 3-3 draw with Stanley which forced the replay, but they received some positive news from the scans and trips to the specialists.
There were fears their campaigns could be over but both are expected to return within four to six weeks.
Striker Tom Craddock came on shortly after half time in Saturday's 1-1 draw having barely trained since his return from a broken rib and he is expected to be involved again.
Accrington boss Leam Richardson will run the rule over experienced forward James Beattie ahead of the tie.
The striker, 34, missed his side's 1-0 defeat to Burton after picking up a niggle in the pre-match warm-up, but could make a full recovery in time to face the U's.
Richardson will be boosted by the return of captain Dean Winnard who served his one-match suspension during the Burton clash.
The defender collected his fifth yellow card of the season during the 3-3 draw against Oxford last weekend so had to sit out on Sunday.
Rotherham loanee Danny Schofield will not be in the side as he is ineligible to represent Accrington in the FA Cup.