AFC Wimbledon will check on strikers Paul McCallum and Luke Moore ahead of the midweek tie.
West Ham loanee McCallum missed Saturday's dramatic 2-1 win over Bradford with an ankle knock and Moore was ruled out due to a shin injury.
Will Antwi remains sidelined after suffering a recurrence of a hip injury last week and fellow defenders Jim Fenlon (back) and Curtis Osano (calf) are still missing.
Jack Midson may have earned a recall in attack after coming off the bench to spark Saturday's comeback with an 83rd-minute equaliser, before fellow forward Gary Alexander hit a last-gasp winner.
Kevin Sainte-Luce came on for his debut in midfield in the second half and is likely to start on the bench again.
Clarke Carlisle will return to the Northampton squad.
Carlisle missed the win over Southend on Saturday through illness but the central defender trained on Monday.
His return presents manager Aidy Boothroyd with a selection dilemma at the heart of the back four, where Ben Tozer and ever-present skipper Kelvin Langmead performed to a high standard at Roots Hall.
Full-backs John Johnson, fit again after a knee injury, and Lee Collins, making his full debut, also enjoyed good games against the Shrimpers.
Midfielder Chris Hackett, who was on the receiving end of a nasty challenge from Southend's Bilel Mohsni which saw him dismissed, completed the game in Essex and will play at Kingsmeadow.