Declan Rudd will come into goal, while the likes of fit-again midfielder Andrew Surman, playmaker David Fox and winger Elliott Bennett are likely to get a chance to impress.
Full-back Steven Whittaker (hip) has resumed full training this week, so could come back into contention.
But centre-half Sebastien Bassong (calf) may be rested again while striker Steve Morison (thigh) and England goalkeeper John Ruddy (thigh) remain sidelined.
With JJ O'Donnell and Jon Shaw available having overcome knocks in recent weeks, Luton have no new injury worries ahead of the cup tie.
But the Hatters will be without cup-tied duo Scott Neilson and Simon Ainge.