Brentford boss Uwe Rosler must decide whether to rest Harry Forrester against Orient.
Rosler admitted three matches in a week had taken their toll on the young midfielder after Saturday's 2-1 home defeat by leaders Tranmere.
Rosler also has the small matter of Sunday's FA Cup fourth-round visit from holders and west London neighbours Chelsea to take into consideration.
Midfielder Kevin O'Connor is still out with an ankle injury and striker Farid El Alagui has a knee problem, but the Bees have no new injury worries.
Full-back Lee Hodson may have earned a start after coming on at half-time against Tranmere while Paul Hayes, Sam Saunders and Jake Reeves are in the frame if Rosler wants to make further changes.
Orient have added Elliot Omozusi to their squad for the trip across London to face the Bees.
Right-back Omozusi has rejoined the O's on a contract until the end of the season, having been released from prison in the autumn.
Manager Russell Slade is still without centre-half Nathan Clarke (ankle) and striker Kevin Lisbie (hamstring).
Slade made five changes to the team which took Hull to extra time in the FA Cup last Tuesday when they travelled to Doncaster at the weekend.
His patched-up side went down 2-0 so further changes could be made with the likes of Lee Cook, Martin Rowlands and David Mooney pushing for starts.
Defender Mathieu Baudry missed out on Saturday with a knock and will be checked over.