The hosts will be without winger Billy Bodin after the former Swindon man joined up with the Wales Under-21 squad ahead of their European Championship qualifier with Moldova on Friday night.
And that international call-up has ruled Bodin out of the Gulls' games with the Spireites and then fellow strugglers York on Saturday.
One player who will return to the squad is striker Elliot Benyon. The Southend loanee was unable to play against his parent club on Saturday but could be reunited with regular strike partner Rene Howe in midweek.
Reading loanee Angus MacDonald is set to continue at centre-back as Aaron Downes serves the second game of his two-match ban, while fellow loanee Jordan Chappell is likely to be involved again after a lively debut at Roots Hall.
The visitors have made the trip without the injured Nathan Smith.
The 26-year-old went off with a foot injury 28 minutes into the Spireites' 1-0 win at Oxford on Saturday.
The club's medical staff are still assessing the extent of the problem but Smith may already be a doubt for Saturday's home game against Plymouth, which sees the return of former manager John Sheridan.
Conor Townsend will replace Smith at left-back at Plainmoor on Tuesday, freeing up a space in midfield.
The fit-again Drew Talbot, Danny Whitaker, Mark Randall or on-loan Manchester City winger Alex Henshall will come into the team.
Jack Lester is also an option for boss Paul Cook, although the veteran striker is usually saved for home matches these days and is likely to be on the bench with the visit of Plymouth just four days after the Gulls game.
Following three starts in eight days at the start of the month, young striker Armand Gnanduillet was absent at Oxford at the weekend with what Cook described as "a few knocks".
Cook thinks it will be a couple of weeks before the Frenchman is ready to play again.