Green was denied the chance to play against Premier League champions Manchester City in the FA Cup fifth round on Sunday after suffering an ankle injury in the build-up to the game.
"Greeny went over his ankle," said under-pressure Leeds manager Neil Warnock, who reported no new problems following the defeat at the Etihad Stadium.
"He was desperately disappointed. He asked if he could have a late fitness test, but I said no. I would rather him be fit for Wednesday, and I would think we will have him back for then."
Warnock also revealed he made his half-time substitutions against City with Wednesday's game in mind. Both Michael Brown and Ross McCormack were replaced at the break in Manchester.
"I wanted to keep Browny and Ross for Wednesday," Warnock said. "Browny is doing brilliant at the minute and he's played a lot of football, and Ross is obviously a big player for us and I want him for Wednesday."
Paddy Kenny is likely to return in goal against Blackpool after Jamie Ashdown was once again used in a cup competition.
Tom Ince is expected to return to the starting line-up when his father takes charge of Blackpool for the first time.
Paul Ince was confirmed as Michael Appleton's successor in the Bloomfield Road hot seat on Monday after agreeing a one-year rolling contract.
Ince Jnr has been in sensational form for the Seasiders this term, netting 17 goals in 33 appearances.
But he only featured from the bench during Saturday's 1-0 defeat to Ipswich, coming after his return from an appeal at UEFA's headquarters in Switzerland against a one-match international ban dating back to England Under-21s' fiery European Championship play-off against Serbia in October.
Matt Gilks returned from suspension at Portman Road and will keep his place in goal.
Elsewhere, left-back Bob Harris is still struggling with a toe injury and fellow defender Ian Evatt (knee) is set to miss the rest of the season.
