Doncaster look like having an unchanged squad for the visit of the Cumbrians.
David Syers, 25, may return to contention after a month-long absence with an ankle injury but Saturday's trip to Johnstone's Paint Trophy winners Crewe seems like a more likely target for the player.
Meanwhile, fellow midfielders Martin Woods (calf) and Paul Keegan (thigh) both underwent scans last week on their respective injuries.
The pair have not completely given up hope of returning before Doncaster's final game of the season at Brentford on April 27, but it seems highly unlikely that either of them will recover in time to play again this campaign.
Rovers boss Brian Flynn named an unchanged side against Tranmere at the weekend. He has options should he wish to freshen things up against the Cumbrians with defenders Paul Quinn and James Husband, midfielder Cameron Howieson and strikers Billy Paynter and Iain Hume ready to come into the team.
Victory for Doncaster would see them stretch their lead at the top of the table to five points.
Carlisle will be boosted by the return from suspension of defender Sean O'Hanlon.
O'Hanlon missed the weekend win at Oldham due to a one-game ban and manager Greg Abbott must decide whether to recall him or retain Peter Murphy alongside Danny Livesey.
Winger Matty Robson has been sidelined for the last two games due to a back problem and remains doubtful, as does defender Frank Simek, who missed out at the weekend because of a thigh strain.
Andy Welsh has returned to the side in place of Robson and is likely to continue, while Abbott hinted Brad Potts could start again if Simek is ruled out.
Recent signing Mathieu Manset is pushing for his first start for the club after four appearances off the substitutes' bench, while fellow strikers Rory Loy, Mark Beck and Danny Cadamarteri and centre-half Mike Edwards are all in contention.