Chairboys boss Gareth Ainsworth looks set to shuffle his pack as his side look for their fourth win in five games.
Ainsworth was delighted with his team's display in Saturday's 2-1 win over Aldershot but admitted he is keen to field a fresh 11 against the Cobblers.
"There could be a few changes because I don't want to make the same mistake of having tired legs out there and not be able to perform at 100%, but then again there might not be any," he told the club's official website.
One player who looks set to return to the squad is midfielder Stuart Lewis, who has completed his two-match ban for 10 yellow cards.
QPR loanee Bruno Andrade (illness) returned to action against the Shots while there were starts for Matt McClure and Dean Morgan (both hamstring) after the attacking duo had sat out Wycombe's last three games.
Chris Hackett will be fit for the visitors. The midfielder came off with a knock after 63 minutes of the Cobblers' surprise 2-0 home defeat to struggling York on Saturday.
He did not train on Monday but boss Aidy Boothroyd said Hackett will do some light training on Tuesday and will be involved in some capacity later that evening.
Should Hackett have to settle for a place on the bench, either Luke Guttridge or Lewis Hornby will come into the starting XI.
Striker Clive Platt is still hampered by a back problem but managed the final quarter of an hour as a substitute against York, and Boothroyd says he will continue to "treat him with kid gloves".
Captain Kelvin Langmead remains on the sidelines with a knee injury but the defender may come back into the reckoning when Northampton travel to Port Vale at the weekend.