Marc Richards may be fit to start for the hosts when John Sheridan returns to his former club with the Pilgrims.
Richards suffered an ankle injury during the draw against Port Vale on April 1 but returned to action as a 56th-minute substitute on Saturday as the Spireites kept their play-off hopes alive with a 2-2 draw against top-seven rivals Bradford thanks to Sam Togwell's injury-time equaliser.
Fellow striker Jack Lester has a back problem and could miss out.
Nathan Smith's absence with a broken foot aside Paul Cook, who succeeded Sheridan in October, has an otherwise fully-fit squad to choose from.
Defender Sam Hird, midfielders Danny Whitaker and Alex Henshall and striker Scott Boden were all on the bench against Bradford and are vying for recalls.
The visitors will be without on-loan winger Jason Banton.
The League Two player of the month for March has been recalled by Crystal Palace boss Ian Holloway after six goals in 14 Argyle appearances.
Sheridan, whose side are three points above the drop zone with three games to go, will also be without Swindon loanee Lee Cox who revealed on Twitter on Monday that he needs surgery on a shoulder injury and will be out for six months.
Ronan Murray's thigh strain meant Argyle did not have their full complement of seven substitutes for the 1-0 defeat at Burton on Saturday but the Ipswich loanee could be fit for the midweek trip.
The experienced Paul Wotton (groin) also has a chance of being available as the Pilgrims look for three points which would ease their relegation fears.