The U's will be without Sean Rigg as they look to cement their place at the top of the table with victory over their local rivals.
The 24-year-old winger is expected to be out for six to eight weeks after tearing a hamstring last weekend in the 3-1 win over Torquay with Chris Wilder likely to turn to Ryan Williams or Callum O'Dowda to fill the void.
Key men Alfie Potter and Dave Kitson will be assessed but should return to action while James Constable is likely to feature after becoming a father in midweek.
The U's third straight win last weekend saw them remain as League Two leaders on goal difference over Southend.
The Chairboys will be without Paris Cowan-Hall for the derby with Oxford.
The winger is set to be sidelined for three to four weeks after scans revealed the winger strained the medial ligament in his left knee on Saturday.
But one player who looks set to be involved is midfielder Billy Knott, signed on loan from Sunderland this week. The 20-year-old has previously enjoyed loan spells with AFC Wimbledon and Woking and should come into contention.
Captain Stuart Lewis will not be involved against their biggest rivals as he is serving the second game of a three match suspension.