Bradford striker Andy Gray could be included in the squad for the first time this season.
The much-travelled 35-year-old has not been involved so far this season due to a broken arm but played in a midweek friendly at York and make the bench.
Defender Rory McArdle has returned unscathed from international duty with Northern Ireland and will be vying with fit-again Luke Oliver for a place in the starting line-up.
Manager Phil Parkinson will monitor the fitness of a couple of unnamed players who sustained knocks during training this week as Bradford bid to maintain their 100% home record this season.
Jeffrey Monakana is poised to make his debut for depleted Colchester against the Bantams.
The winger arrived from Preston on Thursday on a one-month loan deal and goes straight into contention for the trip to Valley Parade.
Forward Sanchez Watt is again likely to miss out due to a thigh injury while Magnus Okuonghae is suspended and fellow defender Ryan Dickson (illness) will again be assessed
But there is some good news for boss Joe Dunne as strikers Gavin Massey (hamstring) and Freddie Sears (groin) are hopeful of making their returns.