Cheltenham defender Ryan Inniss is set to face the U's after a scan gave him the all clear.
The 18-year-old Crystal Palace loanee suffered a calf injury in the 2-2 draw with Portsmouth last week before returning to his parent club, but he has now been given the go ahead to feature against Chris Wilder's unbeaten side.
Steve Elliott will feature again having recovered from his jaw injury to face Pompey, while Jamie Cureton will be in the squad.
The experienced striker has recovered from a dislocated shoulder and will be involved for the first time since the opening day but Troy Brown (hamstring) and Craig Braham-Barrett (ankle) both miss out again.
Oxford are waiting on the fitness of James Constable before naming their side for the trip to the Robins.
The striker limped off in the second half of their 2-0 win at Burton last Saturday after a kick to the foot and the former Kidderminster man has been unable to train since, making him a major doubt.
But Chris Wilder has Deane Smalley fit again and Ryan Williams is also pushing for a start as they look to continue their unbeaten start to the campaign.
New signing Shwan Jalal, who signed on a one-month loan from Bournemouth, looks set to be involved after injuries to fellow goalkeepers Max Crocombe (shoulder) and Wayne Brown (foot).