Romain Vincelot is a major doubt for Leyton Orient's big lunchtime showdown with promotion rivals Brentford.
The midfielder had to go off just 20 minutes into Tuesday night's 2-0 win at Port Vale with a foot injury.
Vincelot's fellow Frenchman Mathieu Baudry has missed the last three matches with a hamstring injury and boss Russell Slade rates the centre-half at 50-50 to be fit.
Veteran striker Kevin Lisbie, who has scored 14 goals this season, could be restored to the starting line-up after he was rested in midweek.
Harlee Dean and Sam Saunders remain Brentford's only absentees for the short trip to derby and promotion rivals Orient.
Dean is close to returning after a groin injury but manager Mark Warburton is taking no risks with him, especially as James Tarkowski is performing well in his absence.
Winger Saunders is also on the mend after a knee operation but is not yet ready to return.
Full-back Scott Barron has finally recovered from the hip injury which has hindered him all season but he could be set for a loan move to build up his fitness.