Wolves will be without Matt Doherty when they welcome Colchester to Molineux.
The former Hibernian defender will be out for two weeks after picking up a hamstring strain during Saturday's 2-0 win against Sheffield United and should be replaced by club captain Sam Ricketts.
Lee Evans, Dave Edwards and Leon Clarke were all handed recalls for the win at Bramall Lane in place of Jack Price, Bakary Sako and Nouha Dicko and could keep their place after being instrumental in a first win in three.
David Davis, Anthony Forde and Jamie O'Hara were all named in the under-21 squad for the Monday night fixture against Bolton and are unlikely to feature.
Colchester boss Joe Dunne could give Freddie Sears a first start in three games when they visit high-flying Wolves.
The former West Ham striker came off the bench last week, following his return from a hamstring injury, and could be rewarded with a return to the starting XI after he inspired a U's comeback from 2-0 down at Bristol City.
Dunne will have no fresh injury concerns ahead of the trip to Molineux but could could call upon the likes of Craig Eastmond, Macauley Bonne and Clinton Morrison should he decide to shuffle his pack.
Colchester have not won on the road in their last four and, with fixtures on the road at Notts County and Peterborough to come, Dunne's team will need to turn around that form if they are to edge further clear of the bottom four.