Defender Matija Nastasic is missing due to an ankle injury but is expected to return to training next week.
New signings Fernandinho, Jesus Navas, Alvaro Negredo and Stevan Jovetic could make their debuts.
Newcastle new boy Loic Remy is a confirmed absentee for their trip to the Etihad Stadium.
The Frenchman has been suffering from a nagging calf problem since linking up with the Magpies in the summer, and boss Alan Pardew has admitted it may take until the end of the month to clear.
Jonas Gutierrez could come into contention after making good progress from a hamstring complaint, and Pardew does not expect any new injury concerns.
The match is live on Sky Sports 1 HD from 7pm.