It means Jozy Altidore is expected to lead the attack and he could be supported by Emanuele Giaccherini, who scored in the midweek Capital One Cup win over Peterborough.
Defensive duo Wes Brown (calf) and Phil Bardsley (foot) remain sidelined as they work their way back to fitness.
Fabio Borini is ineligible to play against his parent club after joining Sunderland from Liverpool on transfer deadline day.
Lee Cattermole made his first start of the season against Peterborough and he could keep his place in midfield.
Luis Suarez is set to start his first Premier League game after coming through his return from suspension against Manchester United unscathed.
The Uruguayan played the full 90 minutes in midweek after serving his 10-match ban for his bite on Branislav Ivanovic and he is expected to keep his place in Brendan Rodgers' starting XI.
Rodgers is waiting on the fitness of vice-captain Daniel Agger after he missed the defeat at Old Trafford with a knock.
Full-back duo Glen Johnson and Aly Cissokho remain on the sidelines through injury meaning Rodgers has a decision to make whether to stick to his 3-5-2 formation he played against Manchester United.
Brazilian playmaker Philippe Coutinho is out after undergoing shoulder surgery last week, while two former Sunderland stars Simon Mignolet and Jordan Henderson are set to face their old club.