Midfielder Mathieu Flamini is likely to go straight into the squad having rejoined his old club this week on a free transfer from AC Milan, as Aaron Ramsey (groin) has recovered, but forward Lukas Podolski is set for up to three months out with a torn hamstring.
Defender Thomas Vermaelen (back) and midfielder Mikel Arteta (thigh) continue their rehabilitation, along with Alex Oxlade-Chamberlain and Abou Diaby (both knee).
With the Gunners' clash in mind, Spurs boss Andre Villas-Boas rested several of his top stars in the midweek Europa League 3-0 win over Dinamo Tbilisi, including Hugo Lloris, Paulinho and Roberto Soldado, who all dropped to the bench and should return on Sunday.
Aaron Lennon was not risked as he recovers from a foot injury, while Emmanuel Adebayor and Benoit Assou-Ekotto did not feature as they continue to be linked with moves away from the club.
Striker Jermain Defoe pressed his claims for a start against the Gunners after scoring a quick-fire brace, as did Lewis Holtby with the third goal.
Tottenham have completed their capture of Steaua Bucharest defender Vlad Chiriches but his signing may have come too late for him to feature in this game.