Robin van Persie's first-half header proves to be the winner and United are now only five points off the pace in the Barclays Premier League title race.
The final whistle blows and the game ends Manchester United 1 Arsenal 0.
Arsenal clear but only for a United throw.
Rooney is down clutching his ankle but United have a free kick half way into the United half and they're taking their time over this.
Arsenal trying to create something on the right and Sagna plays another wonderful ball across the six-yard box which evades everyone. That was a late let-off for United.
United looking very solid still and working hard to close out this match. There will be a minimum of three added minutes.
Gnabry plays a low ball across the box and finds Bendtner but Smalling does well to get across and concede a throw.
Carrick goes down under a heavy Bendtner challenge but no cards this time.
Rooney still motoring around closing Arsenal defenders down and United win a throw on the left before Giggs' throughball goes straight out for a goal kick.
Rooney and Cleverley battling for the ball in the Arsenal half but the away side come away with it and attack down the right.
85 Van Persie is now being replaced by Marouane Fellaini, with Rooney left on as a lone striker.
The corner is over hit and a second cross from Sagna goes out for a goal kick off Vermaelen.
Giroud with a shot on the turn which deflects just wide off a United player.
Gnabry straight into action and he slots the ball into Ozil but he delays too long and United can clear.
82 Arteta withdrawn now for Serge Gnabry as Arsenal look for an equaliser.
It's a lovely ball in from Van Persie and Smalling has a fine chance at the back post but he can't get a clean connection and heads it down into the floor and wide of the goal.
81 Jack Wilshere is the latest name into the book for hauling down Evra. Van Persie will look to swing the free kick over.
The danger is deal with by Arsenal but they give it away again and Giggs wins a throw in on the left.
De Gea comes out to claim a cross from the right and sets United on a counter.
78 Arsenal also make a change and it's Cazorla off for Nicklas Bendtner,
78 Kagawa comes off now, with Ryan Giggs on in his place.
Smalling gets forward on the right wing but his cross is a poor one and flies behind for a goal kick.
Corner to Arsenal on the right comes to Koscileny whose shot is blocked, Gibbs sends it back with purpose but the shot is collected low by De Gea.
75 Rooney booked for a lunging challenge on Ramsey.
Cleverley and Kagawa link well on the edge of the Arsenal area but Koscielny is in the right play to stop Van Persie turning it home after Kagawa's cross.
The corner comes to nothing before Cazorla has his head in his hands after over hitting an attempted cross.
Arsenal mount an attack on the right and Sagna's cross is faultless but it's a Man United defender who gets the touch and puts the ball behind for a corner.
Ozil gives the ball away when looking to break and United look to calm things down.
Arsenal win the midfield battle again but United soon have it back. We're set for an end-to-end last 20 minutes.
United noticeably sitting deeper and Ramsey sends a great ball into the middle but Ozil doesn't seem keen to jump for the header and the danger passes.
Giroud almost finds a way through but he's stopped in his tracks and the attempted cut back doesn't find Wilshere on the edge of the area.
Arsenal are really bossing possession now but not yet able to open up the United back four.
Van Persie and Valencia do well to find Rooney but his chipped effort on goal is all wrong and drifts low and wide of the target.
Cazorla slips a ball through for Wilshere but he's outpaced by Jones and fouls the defender, who was just trying to watch the ball out of play.
Jones deals with the ball into the box but there is nobody upfield for United and Arsenal can launch another attack.
Ozil is trying his hand on the right and finds Sagna in an advanced position. The latter wins a free kick over by the right touch line from a foul by Evra.
Smalling puts in a strong challenge on Gibbs before Giroud heads out for a United throw just inside their own half.
The game is opening up nicely but it's United who are still creating the better of the chances.
61 Jack Wilshere on in place of Flamini.
United pushing forward and Rooney manufactures an excellent chance just inside the area. He does brilliantly before shooting just wide of the post on his left foot.
Ramsey has been in fine form lately but his snap shot from all of 30 yards out is along the ground and straight at De Gea.
Ozil gets the ball back inside the Man United box and slams a shot into the side netting while under pressure from Rooney closing him down.
A poor cross from Ozil on the left is claimed by De Gea but he's adjudged to have carried the ball out and a corner is given.
Van Persie's corner is caught at the back post by Szczesny.
Rooney puts himself about to win a throw on the left before Kagawa earns a corner off Vermaelen on the right.
Arsenal getting their passing moves going a little further up the pitch now, which will surely encourage Arsene Wenger, but the United defence stands firm again.
Jones does well to deal with the first ball and Evans heads the second cross clear before Valencia attempts to break on the right.
Koscielny sends a pass straight out of play to add to the current scrappiness but Arsenal win a corner.
A scrappy passage of play results in a foul by Giroud on Carrick.
The Germany star almost makes me eat my words by drifting past his marker but the pass towards Giroud is intercepted.
Arsenal so far struggling to get their key men on the ball in the middle of the pitch, Ozil having a particularly quiet time.
Vermaelen steps up to strike the long-range effort but his bending shot just keeps rising and De Gea watches it fly way over the top.
Cleverley straight into the action and he's penalised for a challenge on Giroud. Free kick to Arsenal in the centre of the pitch around 30 yards from goal.
Ramsey has a shot blocked by Jones at the other end.
Vermaelen heads the corner clear before Rooney tries a clever lofted throughout which almost finds Kagawa.
Man United force a corner on the right and Van Persie will take it.
Arsenal get the second half started and are immediately put under pressure as Kagawa tackles Sagna.
Vidic has been substituted at half time, with Tom Cleverley coming on.
Our friends at Sky Bet have been in touch offering some half-time PRICE BOOSTS. They include Arsenal to win 2-1 at 14/1 and Mesut Ozil to score next available at 18/1. Man United are 2/5 to go on and complete the victory, an Arsenal win is now 7/1, while the draw is priced up at 3/1.
David Beattie has been in touch at half-time, writing: "Utd are playing very good football, cracking header by Van Persie. Gunners need to reload for 2nd half. I think 2-1 utd."
Tyleri has emailed: "Valencia is back to his very best, just hope he can keep this up. With the centre midfield situation, i think we should have gone for Paulinho, fantastic player."
The first half comes to an end and Man United lead 1-0 after Van Persie's headed goal from a Rooney corner. We're nicely poised for a hugely entertaining second half.
Vidic walks off to receive treatment and does not need the stretcher, which is encouraging.
Van Persie penalised now before Arsenal come forward on the right. Ramsey's cross comes over and De Gea punches clear. In doing so, it looks as though his knee has struck Vidic in the head. This does look another worrying moment at Old Trafford.
There will be a minimum of two minutes added time.
It's gone a little scrappy and Sagna makes a mess off an attempted cross on the right wing. The ball cannons back into his leg off Evra and goes out for a goal kick.
44 A retrospective yellow card is shown to Flamini for a tackle on Phil Jones over a minute ago.
Some snappy challenges coming in now.
42 Jones is booked for the challenge on Szczesny, which looks a shade harsh. The Arsenal man is back up and happy to take the goal kick.
The corner comes in and Szczesny punches clear but the keeper is stricken after the challenge and worryingly stays down.
Corner to United after Sagna and Kagawa come together on the left. That looked the wrong call.
Ozil and Cazoral trying to stamp their prowess on the midfield but Arsenal they give the ball away tamely.
Loose again from Ramsey in the central third and United come forward. Rooney ends up on the deck after a clumsy Giroud tackle and wants a penalty but the referee waves play on.
Valencia fires over a low cross from the right but there isn't much direction on it and the ball flies past everyone before Arsenal give the ball away in midfield.
Ramsey's back heel fails to find Sagna but the ball comes into the United box and Giroud's header goes harmlessly wide.
Arsenal enjoying their first decent spell of possession but it's deep in their own half and United are pressing high up the pitch.
The corner is played short to Ozil whose cross is punched clear by De Gea.
Jones makes a good block on Cazorla, who is opening up his body and shaping to shoot, before Arsenal win a corner on the left.
Ozil crowded out on the Arsenal right before Man United win a throw. The ball is then back to De Gea after Vermaelen's clearance is over hit.
31 The first yellow card of the game is issues to Sagna for a late challenge on Evra, who was looking to break down the left wing.
Ozil's free kick from the right is very disappointing and can't beat the first man.
Arsenal now look to attack with Ramsey playing the ball out to Sagna but his cross is headed out of trouble.
27 GOAL!!! (VAN PERSIE) Who else could it be? Wayne Rooney swings in the perfect corner and former Gunner Van Persie heads the ball into the top corner with just the faintest of touches. United lead after a very quiet start to the match.
Rooney gets some space on the left again and sends over a wicked cross that Vermaelen can only head over his own bar for a corner.
Smalling pulled up for a foul on Cazorla just outside the centre circle.
Koscielny does really well to deal with a breaking Van Persie, playing the ball back off the Holland international to win the throw for the away side.
Both sides looking very solid at the back and Arsenal are clearly sitting deep in the hope to draw United onto them.
Small caught offside after a good run down the right sees Valencia try and find the full back with a short pass.
Rooney plays over a teasing cross from the left but Vermaelen is up to the task again, heading clear.
Rooney reacts quickly to a ball over the top and makes a run down the right but Vermaelen gets across to make a good sliding challenge.
Giroud caught offside and United patiently pass the ball between their back four.
Both sides trying to gain early dominance but there has been no sign of a clear opportunity just yet.
Lovely passing from Arsenal on the right and Giroud comes forward with purpose but is then deemed to have fouled Jones in what looked like a 50-50 challenge.
Ozil goes down on the edge of the Man United area but the referee is unmoved. There wasn't much in it, if anything.
Gibbs forces a throw deep in the United half but Smalling and Valencia clear the danger before Van Persie is penalised for a slight trip on Vermaelen.
Cries of 'oh Robin van Persie' ring around Old Trafford. He hasn't done much yet.
Rooney gets away from his man in midfield and sprints down the left but Sagna is hot on his heels and the England striker loses control and bundles the ball out of play.
Sagna is down holding his thigh for a moment but he's soon back up and hobbling back into position as Man United prepare to take a throw in their own half.
Smalling and Valencia link well before the full back sends a long ball up towards Van Persie He nods down for Rooney but the move eventually ends with a cross from Evra being easily caught by Szczesny.
Shot from Rooney from all of 30 yards and it takes a slight deflection but there's not much power on it and Szczesny can get down to his left to make a comfortable save.
Arsenal finally able to enjoy some possession with some neat touches from Cazorla and Arteta before Gibbs gives it away.
Jones bursts forward after making an interception but he's on his own and ends up running down a blind alley.
Szczesny out to claim a cross from the left and Arsenal then win a throw on the halfway line.
Arsenal yet to get many touches in the opening stages and are happy to get men behind the ball.
Kagawa forward again on the left and he finds Evra but Van Persie's return pass isn't on target.
United seeing plenty of possession early on but nobody able to really put their foot on it in the middle of the field. Not much time on the ball, as you'd expect.
Giroud is penalised for a slightly late tackle on Evans. Replays suggest he's possibly lucky to get away without a booking there.
Early corner for the home side is whipped in by Van Persie but dealt with by the Arsenal defence. United regain possession but are forced all the way back to the halfway line.
Early foul from Jones on Arteta but United win it back and Kagawa sends over a deep cross from the left. Valencia does well on the other side to win a throw.
Andre Marriner blows and Man United get us under way.
A huge roar from the Old Trafford crowd following a minute's silence for Remembrance Day. Strap yourselves in, we're all set folks.
What a massive game for Thomas Vermaelen to come back into the side and the Arsenal club captain is leading his team down the Old Trafford tunnel. We're just moments away from kick-off...
Chris Green from Huddersfield writes: "Come on United! We need to show the rest of the Premier League that we are still capable of retaining our Premier League crown."
Alex Bullions is backing Ramsey to keep up his fine goalscoring streak: "I think that Arsenal have a good enough team to get a win. I predict 2-1. Ozil to assist both and Ramsey to score one as well as Giroud."
We've seen defeats for Tottenham and Manchester City already so what else can this remarkable Super Sunday throw up? Another Arsenal victory would give them a commanding lead at the top of the table, even for this early stage of the season, while a win for United would see them leapfrog their 'noisy neighbours' and put them right back in the mix for the title.
David Tinsley writes: "As an Arsenal fan, I am still hugely nervous about this game. The Salford lot always seem to cause us problems, no matter what form we might be in. I was looking forward to a tight game with counter-attacking from Arsenal, but with both Per and Tomas sick, and apparently Gnabry and Arteta feeling under the weather, I really fear for Arsenal here."
Andy Knowles writes: "For me Fellaini has been a let down since he came to united, would like to see Hernandez see more minutes quality player. Man u win 3-2"
Carl Harding, a self-proclaimed Norfolk Gooner, says: "So many times when big teams play it ends in a dour 0-0 let's just hope it's a good advert for the premier league. My prediction 1-1 with the Arsenal going on to win the league."
Joshua says: "Come on United. Try and get a clean win or even a draw, Good luck lads."
Tyler from Kettering isn't the first person to question David Moyes' starting line-up, writing: "Would like to have seen fellaini start and bully the midfield. Hoping for a united win to kick start our season. Need rooney on top of his game. COME ON UNITED!!!!!"
Matt Moores writes: "Arsenal are in fantastic form but I just can't see Man Utd losing this one, they need a huge win and a loss would put a huge dent in moyes potential longevity at Old Trafford. 2-1 Utd."
Stephen from Manchester says: "Massive game for United today, biggest since Madrid in Champions League. Arsenal are playing brilliant atm but going for a 3-1 man utd win with Rooney & Van Persie on scoresheet."
Don't forget you can also bet live in-play with Sky Bet after the match has started. The PRICE BOOSTS are coming thick and fast ahead of kick-off, with Shinji Kagawa out to 16/1 from 12/1 to score first, while Arsenal to win 1-0 is out to 12/1.
Stephen from Ireland, says: "As a united fan in an Arsenal family I'm hoping we get a sneaky win today but Arsenal's midfield is the best in the league, not one of United's would get into theirs."
Many thanks to Omar Willis from Jamaica, who writes: "After this victory Arsenal will be rightfully installed title favourites, of course I already know that."
Joe from Manchester doesn't seem best pleased with the home team, writing: "Just seem the line up, today's game was a must for Januzaj!!!"
Mark from Papworth says: "Massive game for United. We lose today then it's a case of playing for 3rd or 4th. 1-1 is all I can see."
Manchester United: De Gea, Smalling, Vidic, Evans, Evra, Valencia, Jones, Carrick, Kagawa, Rooney, van Persie. Subs: Lindegaard, Giggs, Hernandez, Nani, Cleverley, Fellaini, Januzaj.
Arsenal: Szczesny, Sagna, Vermaelen, Koscielny, Gibbs, Arteta, Flamini, Ozil, Ramsey, Cazorla, Giroud. Subs: Fabianski, Jenkinson, Monreal, Hayden, Gnabry, Wilshere, Bendtner
Thanks to Chris in Manchester for getting in touch with: "Afternoon. What a great start to the best league in the world - so many surprise results! Reckon united will manage to grab a win although arsenal playing some lovely football! 2-1 united!"
Stu Sharp is praying: "Going to be tight today but if the football Gods are with us I really believe Man Utd can win today 2-1."
Rob Davies has this to offer: "2-1 Arsenal for me today. Rooney, Giroud and Ramsey with the goals. A red card for Vidic in there too!"
Paul Walters writes: "Big big game, with so much on it for both sides, being a neutral I can stay calm, but I reckon if not a draw, Arsenal may just edge it."
Josh Bell writes: "Big game today going for a 2-1 win for united, battle will be won in midfield although I expect united to sit back and try and hurt Arsenal on the counter, would love to see kagawa play behind RVP like he did against Sociadad, he opened up so many pockets. COME ON UNITED!!"
Big stuff from Mohammed Usmaan, who says: "This is a must win game for Man United as it is THE TITLE DECIDER. If they lose or draw then they have no chance of retaining their title. This is a double game as it will be like 6 points to the winning team."
Tom Hanaphy: "I think whoever wins this will go far this season. I think Man Utd will want and need this more though so my prediction is a 3 - 0 home win."
Will Birley is in fact sensing a spot of deja vu, writing: "I am a United fan and i have actually put a bet on 8-2! I can really see United buckling down now in the season and taking advantage of other teams dropping points, If RVP and Rooney are on their games today I am sure we will get the three points. UNITED!"
I will be bringing you the team news as soon as possible but before that why not head to Sky Bet to place all your pre-match bets. One of the many attractive PRICE BOOSTS on offer for this match is the red-hot Aaron Ramsey to score first at 11/1.
I can't wait to hear your thoughts and predictions ahead of this massive Super Sunday clash so do get in touch at email@example.com and I'll endeavour to post as many of your comments as I can. Anyone fancy a repeat of the 8-2 scoreline we saw in this corresponding fixture a couple of years ago? I have my doubts...
Good afternoon everyone and welcome to our live interactive text commentary of Manchester United v Arsenal at Old Trafford. And what a thrilling encounter it promises to be, with Arsene Wenger's Gunners flying high at the top of the league and David Moyes still getting to grips with life at the helm of one of the biggest clubs in world football.
Updates will appear here...