Stephen McManus, Shaun Hutchinson and Iain Vigurs have shaken off knocks and will feature in the first leg clash at Fir Park.
All three were substituted during Motherwell's 1-1 friendly draw with Nottingham Forest on Friday but have been declared fit for the European clash.
Estonia striker Henri Anier is also available after his loan move from Viking Stavanger was completed.
But 19-year-old defender Euan Murray has been ruled out with a hamstring injury and will miss the game.
The Russian side are three games into their season and sit fifth after a win and two draws in the Premier League.
Motherwell manager Stuart McCall : "We've learned quite a lot about them. We've seen all three league games they've played so we have been fortunate in that regard.
"We are well-informed and hopefully the lads know their roles and responsibilities. Then it's just about going out and playing to our maximum and playing at our best, which we will need to do."