The Gills could hand a full debut to Danny Hollands in the first round of the Football League Trophy.
The on-loan Charlton midfielder made his Gills bow from the bench at the weekend and is pushing for a first start against the League One pacesetters.
Midfielder Amine Linganzi is still struggling with a hamstring problem while right-back Matt Fish (cruciate ligament) is a long-term absentee.
Boss Martin Allen could hand a start to Cody McDonald in attack as his side chase their first win of the campaign.
Leyton Orient have a fully-fit squad for the trip to Gillingham in the Johnstone's Paint Trophy.
Defender Mathieu Baudry (hip), midfielders Moses Odubajo (knee) and Marvin Bartley and striker Shaun Batt (both hamstring) all shook off recent injuries to feature in Saturday's 2-1 win at Colchester - the O's fifth win in five League One matches this season.
Boss Russell Slade does not have much room to make changes among his small squad but Bartley and Batt might be handed starts having been used predominantly as substitutes so far this term.
Veteran striker Kevin Lisbie could be due a rest having scored five goals in seven matches already this season.