Dons boss Karl Robinson is expected to make changes to his side for the first round tie at home.
Ian McLoughlin keeps goal in cup competitions and he is likely to replace David Martin. Jon Otsemobor, Luke Chadwick, Alan Smith, Ben Reeves, Dele Alli and George Baldock were also on the bench for the 1-0 league win at Sheffield United on Saturday and will come into contention for starting roles.
Lee Hodson is away on international duty with Northern Ireland while fellow full-back Dean Lewington returned from four weeks out with a knee injury against the Blades and will probably be rested after playing the full 90 minutes in South Yorkshire.
Loan players Patrick Bamford, Jason Banton and Samir Carruthers are available but Daniel Powell (ankle) and Dean Bowditch (groin) remain sidelined.
The Cobblers are without Roy O'Donovan for the trip south east.
The two-goal striker was dismissed during the 1-0 defeat to Bristol Rovers at the weekend and sits out a one-match suspension.
Left-back Joe Widdowson (hamstring), midfielder Ian Morris (groin) and winger Danny Emerton (illness) are all doubtful after missing Saturday's defeat.
Recent midfield signing Matty Harriott will look to make his Cobblers debut, having been an unused substitute against the Pirates.