Bryan Oviedo is the Everton hero tonight in a match which will have major repercussions on the title race. Stay with us for a full match report and all the best post-match reaction.
Roberto Martinez has achieved at his first attempt what David Moyes could not in 11 matches - guide Everton to victory over Manchester United at Old Trafford.
ALL OVER! Everton have won at Old Trafford for the first time since 1992.
Rooney is penalised for handball.
Long-range effort from Lukaku flies wide of De Gea's goal.
Free-kick for Everton on the edge of their own box as Januzaj tangles with McCarthy.
Mirallas makes way for Naismith.
Four minutes of added time will be played.
Wasteful from Delofeu as he has space down the right and Lukaku in the middle, but he can only chip the ball straight into De Gea's hands.
Not long to go for United to force their way back into this game. They've hit the woodwork twice, but now Everton have forged ahead.
Everton keep the pressure on and Lukaku drives the ball across the face of goal where Bryan Oviedo arrives unmarked to drill the ball beyond De Gea!
GOAL FOR EVERTON!!!!
Superb effort from Mirallas! So close to the opener as the free-kick goes up and over the wall only to be denied by the outside of the post.
Valencia takes out Coleman and Everton have a free-kick in a dangerous position outside the box and to the left.
Now Vidic is penalised for a hefty challenge on Osman.
Nani's handball is eventually spotted by the officials, but Everton fail to make the free-kick count.
Fellaini gets away with catching McCarthy high up on the back of his thigh with his studs raised. No action from Atkinson. Should have been at least a booking.
Hernandez comes on for Welbeck, even though Vidic is limping at the back.
Pienaar is replaced by Osman for Everton.
Finally, some respite for Everton, as they can hold onto the ball for a spell and craft an attack of their own.
Another important clearance from Distin as he launches the ball away after more good work from Nani.
Superb skill from Nani out on the left to lose his man before swinging over a dangerous cross which is between goalkeeper and defenders, but there are no attackers gambling at the far post.
Giggs swings the free-kick over, but Howard is able to fist away.
Januzaj is on the turf again after getting away from Oviedo, with Atkinson giving a free kick on this occasion.
Januzaj finds fellow sub Nani on the edge of the area, with the Portuguese winger showing quick feet, before firing his shot wide.
GREAT SAVE AND THEN OFF THE BAR!!! Superb stop from the Everton keeper to deny Evra's close-range header before Welbeck's follow-up comes back off the face of the bar. United continue to press, but Rooney then lashes a shot horribly over.
The ball drops to Fellaini at the far post, he takes a touch to set himself for a shot, which is deflected behind.
And we're back at the other end of the field, with Howard forced to tip over a stinging, swerving effort from Januzaj.
Immediate chance for Deulofeu, as he escapes down the right but can only fire straight at De Gea. Big chance missed for Everton.
First change for Everton, with Deulofeu on for Barkley.
Just seen a replay of the penalty appeal. Pienaar steps across Januzaj, but the United man goes to ground very, very easily.
Januzaj tricks his way into the area and than falls to the ground with more than one Everton defender in attendance. Referee Atkinson is utterly disinterested in the youngster's penalty appeals.
Giggs loses the ball to Mirallas in his own half, but Atkinson has spotted a foul from the Everton man.
Nani plays the ball beyond his man in the vague direction of Fellaini and attempts to chase his own pass, but Everton clear.
Good control and possession for United as they look for a way though the Everton defence.
Another clash between Lukaku and Vidic on the edge of the United area, with the central defender coming out on top on this occasion.
Nani attempts to feed Welbeck, but Jagielka gets to the ball first and clears once again.
Atkinson allows play to go on, before booking Rooney for catching Jagielka with a raised elbow after the ball has gone. He'll now miss the forthcoming game with Newcastle.
Strong, but fair, challenge on Rooney by Jagielka, who is then caught by his England team-mate after the ball has gone.
Valencia has dropped in at full-back with Rafael having departed, with the new men both bolstering the midfield.
Rooney whips the free-kick into the box but Everton clear. United regain the ball and Nani has an early sight of goal, but gets his shot all wrong and fires woefully over the bar.
Double change first, with Kagawa and Rafael the men to make way for Nani and Januzaj.
Coleman is penalised for bringing down Giggs, with United having a free-kick out on the left.
In fact, it looks as though Januzaj will be coming on too.
Nani is set to join the fray as United prepare their first substitution.
Another good spell from Everton, with Mirallas dropping his shoulder to get away from Evra before firing in a shot from outside the box in a central position which flies wide of the goal.
Smalling is then forced to hack clear as Coleman and Barkley combine to almost set up Mirallas for a shot in the box.
Nervous moment for Distin, as he shows too much to Valencia, only to recover well and calmly clear his lines.
Great pace to this game as play switches from end to end, with Giggs' attempted ball over the top too Rooney just too strong.
Good play initially from Valencia to burst clear and find Rooney, who returns the ball to the midfielder, but his cross is poor and easily cleared.
Shooting chance for Fellaini from range, but his shot is blocked by McCarthy for a corner, with Rooney's kick eventually gathered by Howard.
Sloppy play from Everton gives Rooney the ball, his attempted pass to Welbeck is accurate, but Jagielka is across to slide in.
And it's completely wasted as Mirallas and Oviedo make a hash of an attempted short corner.
Corner for Everton as Smalling blocks Barkley's attempted cross.
Evra fires in a long-range effort which stings Howard's palms at the start of the half, after Distin's poor clearance had allowed Rafael the chance to cross.
Everton get the second period under way.
The two teams are back out for the second half.
Rooney's deflected effort which struck the base of the post is the closest we've come to a goal, although Lukaku has kept Vidic and De Gea honest with some powerful play.
Referee Atkinson brings the half to a close.
Some slack play at the back for United by Giggs before Rafael clears.
Pienaar is spoken to by Atkinson after a late challenge on Valencia.
One additional minute will be played.
Barkley plays in Oviedo down the left, but Rafael gets back and Atkinson gives a goal-kick.
Back down the other end now, with Evra's low cross evading Welbeck, before Oviedo's hashed clearance is flicked goalwards in an improvised move from Rooney, but Howard can claim.
Barkley bursts from deep and, with the United defence in retreat, has options left and right. He attempts to find Lukaku, but puts far too much on the pass and the chance is gone.
Well-timed sliding challenge on Valencia by Oviedo gives United another corner, but Giggs' kick is headed away by Lukaku.
Stunning cross-field pass from Barkley finds Lukaku, who makes space for the shot which De Gea saves with his legs. Coleman picks up the ball and cuts it back, but Smalling is there to block.
More solid defending from Everton as they hold out despite good pressure from Rooney, Giggs and Evra. Play then switches to the other end, where Lukaku is penalised for being too physical with Vidic. Good battle between those two tonight.
Barkley is too strong for Fellaini as he out-muscles the Belgian before making space for a shot, only to see it curl away from De Gea's goal.
Decent spell from Everton as they look to relieve the pressure on their defence, but the attack ends as Mirallas fails to keep the ball in play by the corner flag.
More good play from Coleman and Mirallas down the right, before Lukaku attempts to feed Barkley on the edge of the box, but the duo are on different wavelengths.
Giggs, Rafael and Valencia work some space on the right, with the Welsh veteran attempting an audacious pass with the outside of his foot to find Valencia, but there is just too much on the ball.
Everton's defence has come under some sustained pressure in the last 20 minutes or so, but they're standing up well so far.
Giggs' out-swinger is aimed at Vidic, but the centre-back cannot make clean contact and Howard can gather.
Valencia's cross causes consternation in the Everton defence with Welbeck and Rooney lurking before the visitors clear. United attack again and force another corner.
OFF THE POST!!! Rooney takes a shot from outside the box which deflects horribly off Distin and leaves Howard rooted to the spot, only for the grateful goalkeeper to see the ball strike the base of the upright before he slides in to hack clear.
Vidic feeds Rooney, who then finds Evra charging down the left, but Barry gets back to challenge well.
Rooney's kick is to the near post and cannons off Smalling and out for a goalkick.
United force a corner as Valencia attempts to run Oviedo and the Everton man slides in to put the ball out.
Great play from Lukaku as he knocks Vidic off the ball out on the right flank, but Smalling comes to his team-mate's rescue as he cuts out the attempted cross.
CLOSE FROM GIGGS! The United veteran gets ahead of his man in the box to glance a header narrowly wide of Howard's goal after a fine cross in from the right flank.
Surging run from Welbeck after a good pass from Fellaini before he is halted on the edge of the area by a challenge from Jagielka. United are appealing for a free-kick, but Atkinson waves play on.
GOOD SAVE! Howard has to race off his line to deny Kagawa, who found the ball at his feet in space in the area after a slightly fortuitous deflection on the edge of the box.
Lukaku muscles his way into the area, but has the ball taken off his toe by Fellaini just as he prepares to pull the trigger.
Good combination between Mirallas and Coleman again, with the on-rushing full-back managing to get a low cross in, which De Gea drops on to gather.
Play immediately switches to the other end and Howard has to come to the edge of his area to gather the ball ahead of Rooney, before releasing it as his momentum carries him out of the area. The crowd appeal for handball, but Atkinson is not interested.
Good attack from Everton as Mirallas feeds Coleman down the right, he attempts to take on Evra, but the Frenchman is far too experienced and clears with ease.
Pienaar leaves the field briefly for some treatment after being caught by Welbeck in the build-up to that United chance.
Welbeck breaks forward before being felled by Distin, referee Atkinson waves play on, but United allow the chance to slip away. Rafael then crosses to the far post, before the ball comes to Rooney and he forces an excellent save from Howard.
Evra breaks forward after Lukaku loses the ball, but his cross has too much power for Rooney in the area and lacked the accuracy to trouble Howard as it flew across goal.
Good spell of possession from United as they search for an opening, before Welbeck loses the ball on the edge of the Everton area.
Everton's dangerous spell sees Moyes on his feet in the technical area, barking instructions to his team.
GOOD SAVE! Mirallas forces De Gea to fist the ball over his own crossbar with a vicious effort from outside the box after cutting inside from the left.
Pienaar's corner is flicked on at the near post by Mirallas, but although the ball goes right across the six-yard box, there is no blue shirt there to convert.
Quick break from Everton sees Lukaku with another sight of goal, but his shot is blocked by Vidic this time.
A short back-pass from Jagielka gives Rooney the scent, but Howard gets to the ball first, only to shank his clearance horribly, but Everton escape.
Kagawa takes a forward pass on his chest and attempts to divert it down the line towards Valencia, but is unable to control the ball and it drifts out.
First shot in anger comes from Lukaku as he turns away from Smalling and fires towards goal, but the ball is always drifting harmlessly wide of De Gea's net.
Leighton Baines, who is out injured with a broken toe, is among the Everton squad on the bench, supporting his team-mates against the side who covet his signature.
Rafael clips a ball down the right touchline towards Valencia, but Distin comes across to clear the danger.
Mirallas clips the ball in towards the back post, but Lukaku is too far forward and jumps under the ball, allowing United to clear.
Early free-kick for Everton in United territory some 35 yards out as Giggs brings down Barkley.
Tonight's referee is Martin Atkinson.
United get the action under way.
There will be a period of appreciation prior to kick-off to the late Bill Foulkes, the Busby Babe and Munich survivor who sadly passed away recently.
A huge roar from the United faithful and the visiting Everton contingent greet the players, who go through the pre-match formalities and handshakes.
The two teams are in the tunnel and ready to make their way onto the Old Trafford surface.
Since their shock home defeat to West Brom at the end of September, United have staged something of a resurgence, going unbeaten through their next 12 games in all competitions. Despite that run, they remain nine adrift of leaders Arsenal, with the ground they made up with victory over the Gunners evaporating with successive draws against Cardiff and Tottenham.
Ruairi Farrell writes: "This is a must-win for United and David Moyes. Expecting a big game from Rooney, Kagawa and hopefully Fellaini. Going to be tough to stop Lukaku but with Rafael back I think United will edge the victory."
Matt in Kettering has been gazing into his crystal ball and reckons: "Rooney to score early on and Lukaku to equalise just after half time... Tense half hour with Everton knocking on the door, then Fellaini to break his old fans' hearts and be the hero scoring late on with a trademark header!"
Stefan Howarth writes: "I'm not too optimistic about tonight. Can see Moyes being conservative so he doesn't lose against his former club."
Opta stat No.4: The last time Romelu Lukaku faced Manchester United, he scored a hat-trick for West Brom in May 2013. He is one of only three players to score a Premier League hat-trick against Manchester United (after Dirk Kuyt and David Bentley).
Opta stat No.3: Manchester United have scored more goals against Everton than any team against any single opponent in Premier League history (84).
Opta stat No.2: Everton have won none of their last 20 Premier League away games at Old Trafford (W0 D4 L16).
Opta stat No.1: Chelsea (twice) are the only team to prevent the Red Devils from scoring in their last 74 league matches at Old Trafford.
Time for a couple of stats from our friends at Opta prior to kick off (Everton fans may want to look away now....)
Steve in Salford says: "Big game tonight, three points required for United. Played some good football going forward in the past few weeks, the unbeaten run is pleasing, need to convert those draws into wins and get some momentum going with games coming fast. Going for a ambitious 3-0 win with Rooney, Fellaini and Wellbeck on scoresheet."
Bernie Cranny reckons: "I believe Everton will win this game 2-0, no trouble. Everton are a team that control games and keep the ball well as a team with a potent attack. United are all over the place playing a different team every week."
Stewart MacLaren has been in touch from a cold and windy Torrevieja in Spain (I reckon it's colder and windier over here....) saying: "Everton will draw 2-2 with Manchester United at Old Trafford tonight with good goals from Ross Barkley and Romelu Lukaku."
Huddersfield-based United fan Chris Green says: "Although United have been hit and miss so far this season, I firmly believe that the title race is still wide open, so let's show the rest of the Premier League that we mean business. Come on United!"
Sean Povey has been in touch via Twitter to say: "Very glad to see Rafael back in the side, Smalling plays OK there, but Rafa is better on the attack, United to win 3-2. #MUFC"
Roberto Martinez is aiming to do something David Moyes did not manage in 11 attempts - win at Old Trafford - and has made two changes with Ross Barkley and Kevin Mirallas replacing Leon Osman and Gerard Deulofeu.
Robin van Persie (toe and groin) is still absent, but Marouane Fellaini has been given the nod to face the team he left in the summer, coming in for the suspended Phil Jones.Rafael is selected ahead of Jonny Evans, and the evergreen Ryan Giggs gets the nod over Tom Cleverley.
Tim Howard is out warming up on the Old Trafford surface, resplendent in yellow boots and gloves and his black training gear. It's so cold here even the bearded goalkeeper has opted for a snood during his pre-game preparations against his former club.
If you want to have your say on tonight's clash, then drop me a line to email@example.com or via Twitter @skysportsrobp and I'll publish a selection of the best in the run-up to kick-off.
Everton subs: Robles, Heitinga, Jelavic, Deulofeu, Naismith, Osman, Stones.
Man Utd subs: Lindegaard, Evans, Hernandez, Nani Young, Cleverley, Januzaj.
Everton: Howard, Oviedo, Distin, Jagielka, Coleman, McCarthy, Barry, Pienaar, Barkley, Mirallas, Lukaku.
Manchester United: De Gea; Rafael, Vidic, Smalling, Evra; Valencia, Fellaini, Giggs, Kagawa, Welbeck; Rooney.
The team news is expected shortly and we will bring it to you as soon as we have it.
David Moyes comes up against his former club for the first time since his summer move from Goodison Park to Old Trafford, with his new employers trailing Everton by two points in the Premier League table.
Good evening and welcome to our live and interactive commentary on tonight's clash between Manchester United and Everton.