The Portuguese boss has already expressed his annoyance at the fact Spurs have to play again just two days after their Premier League game at Cardiff.
And very few of the players who featured in the 1-0 victory in the Welsh capital are expected to be in action again at Villa Park.
Brad Friedel, Erik Lamela, Lewis Holtby, Sandro and Vlad Chiriches are all possible starters but forward Jermain Defoe is doubtful with a groin strain.
Key Villa forward Christian Benteke had to be substituted during the first half of Saturday's 1-0 victory at Norwich after injuring his hip.
The injury is currently being assessed and the Belgian will probably not be in the line-up against Spurs.
Libor Kozlak, who came off the bench to score the winner on Saturday, is therefore likely to make a first start for the club, but Gabby Agbonlahor, Fabian Delph, Ashley Westwood and Antonio Luna are all injury concerns.