Exeter will assess goalkeeper Artur Krysiak before they host Morecambe on Tuesday night.
The Polish shotstopper had been an ever-present for the Grecians this season until his picked up an injury in the 1-1 draw with Portsmouth which saw 18-year-old Christy Pym handed his first appearance for the club at Southend on Saturday.
And youth product Pym looks set to make his home debut if Krysiak is not passed fit to face the Shrimps.
Bristol Rovers loanee Eliot Richards stepped off the bench to score the winning goal at Southend on Saturday and he will also hope to make his first start at St James Park.
Morecambe midfielder Alex Kenyon will complete a three-match suspension at Exeter.
Kenyon was dismissed in the game at Accrington, which was later called off due to a waterlogged pitch and will sit out again for a Shrimps team without a win in seven games.
The trio of Mark Hughes (hamstring), Andy Fleming (knee) and Robbie Threlfall (head) overcame injuries to start on Saturday, all completing 90 minutes despite their respective problems.
However, winger Marcus Marshall, who has had an injured blighted time at the Globe Arena, is still at least another week away with a hamstring problem.