Marley Watkins and Greg Tansey drop out after being sent off during the 5-0 reverse to Dundee United in the Scottish Cup on Sunday.
The duo join the already banned Ross Draper on the sidelines, although all three will be available for this weekend's League Cup final against Aberdeen at Celtic Park.
Manager John Hughes has hinted he will give some players a chance to earn a place in Sunday's team, and is hoping for a confidence boost against his former club after two heavy defeats in their last two games.
Hibs will have Tom Taiwo available for selection at the Tulloch Caledonian Stadium after the midfielder completed a suspension.
On-loan Sunderland winger Duncan Watmore has returned to training after a foot injury but is not certain to feature.
Midfielder Kevin Thomson continued his return to fitness by playing for the U20s on Tuesday, but will not be risked in the Highlands.
Scott Robertson has a knee injury and fellow midfielder Owain Tudur Jones is also absent because of a hamstring problem.